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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by honeybee on May 10, 2006, at 15:45:23
An article I uncovered about SAM-e says the following:
It has been cautioned that SAMe be avoided in patients with Parkinson's Disease. Animal Studies indicate that excessive methylation is associated with Parkinson's disease and SAMe excess has caused Parkinson's disease-like effects in animal studies. In addition both animal and human studies indicate that increased methylation can cause the depletion of dopamine and block the effects of L-Dopa. this line of research is contradicted, however, by preliminary evidence that SAMe may improve the emotional depression and the impaired mental function that is often associated with Parkinson's disease. Nonetheless, it is recommended that patients with Parkinson's disease avoid supplementing with SAMe until more is known.
How high a risk is there of Parkinson's in drugs that increase dopamine and/if there is this risk, then what happens when it happens. Reversible? Not?
Posted by Declan on May 10, 2006, at 17:42:11
In reply to SAMe: Risk of Parkinson's?, posted by honeybee on May 10, 2006, at 15:45:23
Hi Honeybee
I am pretty uninformed, but here's my take on it. The animal study might be the one where SAMe was injected into the brains of the animals. So there's that, physical injury, unnatural circumstances thing.
Secondly, if SAMe has any adverse effect on Parkinsons etc it may be because of the effect SAMe has on serotonin, not dopamine. This is just what I remember from an article in a Life Extension magazine a few years back.
Declan
Posted by linkadge on May 11, 2006, at 16:39:19
In reply to Re: SAMe: Risk of Parkinson's?, posted by Declan on May 10, 2006, at 17:42:11
I remember reading about this concern. I'd like to hear more if anyone ever hears.
Linkadge
Posted by nolvas on May 11, 2006, at 17:27:00
In reply to Re: SAMe: Risk of Parkinson's?, posted by linkadge on May 11, 2006, at 16:39:19
Check out the above study. That's possibly where the concern arose, from that study or similar ones.
Posted by linkadge on May 11, 2006, at 18:01:19
In reply to Re: SAMe: Risk of Parkinson's?, posted by nolvas on May 11, 2006, at 17:27:00
Well that sucks. Theres no such thing as a good supplement anymore.
Linkadge
Posted by linkadge on May 11, 2006, at 18:03:14
In reply to Re: SAMe: Risk of Parkinson's?, posted by nolvas on May 11, 2006, at 17:27:00
At one point low methylation was implicated in all neurodegeneritive disorders, and now excess methylation is implicated.
Linkadge
Posted by jakeman on May 11, 2006, at 20:52:52
In reply to SAMe: Risk of Parkinson's?, posted by honeybee on May 10, 2006, at 15:45:23
I would be cautious about forming any solid conclusions based on this study. They injected it into the brains of rats.
warm regards, Jake
> An article I uncovered about SAM-e says the following:
>
> It has been cautioned that SAMe be avoided in patients with Parkinson's Disease. Animal Studies indicate that excessive methylation is associated with Parkinson's disease and SAMe excess has caused Parkinson's disease-like effects in animal studies. In addition both animal and human studies indicate that increased methylation can cause the depletion of dopamine and block the effects of L-Dopa. this line of research is contradicted, however, by preliminary evidence that SAMe may improve the emotional depression and the impaired mental function that is often associated with Parkinson's disease. Nonetheless, it is recommended that patients with Parkinson's disease avoid supplementing with SAMe until more is known.
>
> How high a risk is there of Parkinson's in drugs that increase dopamine and/if there is this risk, then what happens when it happens. Reversible? Not?
Posted by honeybee on May 12, 2006, at 10:24:49
In reply to Re: SAMe: Risk of Parkinson's?, posted by jakeman on May 11, 2006, at 20:52:52
Yeah, there are downsides to everything. Too much water can kill you, despite your need for fluid, so I would assume that it's a simple calibration issue.
Still, it's enough to make a person want to chuck Western medicine, have her pulse taken, and get a pattern diagnosis from an L.Ac. that makes a bit more sense, based on the individual, rather taking a pill prescribed by a one-size-fits-all understanding of a particular illness.
This is the end of the thread.
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