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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 17 of 17. This is the beginning of the thread.
Posted by robot on May 24, 2006, at 13:49:56
Has inositol pooped out for you?
I just started about a week ago and its really helping me--the first suplement to do much for me (fish oil has helped some too) so I hope I can keep using it though Im willing to take weeks off it so my body doesnt get too used to it. Ive been taking about 2 grams twice aday, sometimes a little more (6 grams/day).
Ive felt tired the past few days though and I wonder if it could be the inositol--perhaps its depleting my other B vitamins or something? Has anyone experienced fatigue on this? COUld be something else, I dont know.
Are there a few particular supps that would be most valuable taking along with the inositol?
Thanks for any info you can give me.
Posted by blueberry on May 26, 2006, at 17:14:57
In reply to inositol questions, posted by robot on May 24, 2006, at 13:49:56
I'm just curious what symptoms you are treating with inositol. Depression? Amxiety?
What benefits have you felt so far?
Posted by robot on May 28, 2006, at 21:11:53
In reply to Re: inositol questions » robot, posted by blueberry on May 26, 2006, at 17:14:57
A long chronic depression, I guess, not feeling anything, being absolutely bored and flat. It hasnt fixed everything, but Ive felt more like myself. Its also helped with appreciating things visually. The intense anxiety that can take me over at times has really been voided by it--however Im doing other things right now that are helping also. Inositol though seems to potentiate those things.
I just seem to be sensitive to getting fatigue if my chemicals get played around with I think. Im going to start the inositol again and just stick with a moderate dose everyother day or so.
Have you tried it? I wonder how many people find that its a part of their solution. very interesting supplement i think.> I'm just curious what symptoms you are treating with inositol. Depression? Amxiety?
>
> What benefits have you felt so far?
Posted by nolvas on May 29, 2006, at 17:04:54
In reply to Re: inositol questions, posted by robot on May 28, 2006, at 21:11:53
I'm trying Inositol again (ordered 1KG, optimistic maybe heh)
Anyway I've been researching dosage and I've found a dosage regime on this page...
http://www.ngine.de/index.jsp?pageid=4176
Look at step 6 further down the page.
Ok this doesn't relate to anxiety or depression but I've seen similar dosage regimes for those conditions and this is something I'm going to follow. Studies generally use much higher amounts to gain a quick response. It seems sensible to try and use a regime like this to work out your dosage response.
There's also some additional information on that page that suggests it may work synergistically with 5HTP. (not a supplement that I'm friends with to be honest)
I'm going to quote a couple of relevant paragraphs here so that it's recorded on this forum in case it's of value in the future to some one, in the event that site goes down permanently.
"6. It can be built up according to the following schedule (1 teaspoon=2 grams, and be sure to use a measuring spoon) for an adult:
Week 1 - 1 teaspoon/2x per day
Week 2 - 1 teaspoon/3x per day
Week 3 - 1.5 teaspoons/3x per day
Week 4 - 2 teaspoons/3x per day
Week 5 - 2.5 teaspoons/3x per day
Week 6 - 3 teaspoons/3x per dayA child can be built up to 3 teaspoons per day over the same six week period. Dosages for adolescents can be adjusted according to weight. In either case, it is best to allow side effects to be the guide. If they begin to occur, it is not considered wise to increase the dosage unless they subside.
Once a person has reached either the maximum dosage, or the greatest amount they are able to tolerate, it is best to try staying six weeks at that level to see if there is any noticeable improvement. If there is none by the end of that time, it should probably be discontinued. As with any treatment, those who are absolutely positive that it will help are only setting themselves up, and may wind up more than disappointed. Everything works for someone, but nothing works for everyone."
Posted by robot on May 30, 2006, at 16:11:14
In reply to Re: inositol questions, posted by nolvas on May 29, 2006, at 17:04:54
Thanks, nolvas. I think Ill start again in the next few days and do just a Tsp everyday or so and build up very slowly.
Are you just about to start your trial of it? Good luck, hope it helps you.
Does anyone know if theres a best way to take it, with meals or just with water?
Posted by nolvas on May 30, 2006, at 20:54:55
In reply to Re: inositol questions, posted by robot on May 30, 2006, at 16:11:14
I got the Inositol today (30th May) took 4 grams, felt pretty much unwell soon after taking it, typical anxious reaction so I'm ignoring that. I have taken Inositol before but not done a proper trial.
Yeah I'm hoping it works too :) I have 1KG so unless I really can't tolerate it then I will carry on and give it a long trial.
Posted by Meri-Tuuli on May 31, 2006, at 5:53:56
In reply to Re: inositol questions, posted by nolvas on May 30, 2006, at 20:54:55
hey nolvas,
you live in the UK right? If so, where did you get the inositol? I'm having trouble finding some.
Kind regards
Meri
Posted by nolvas on May 31, 2006, at 6:19:41
In reply to Re: inositol questions » nolvas, posted by Meri-Tuuli on May 31, 2006, at 5:53:56
I bought mine from bulknutrition.com. I got 1KG and it worked out to be around £35 including the shipping, very very cheap! Not sure if I will get a customs bill though, you just never know with them.
The delivery took about 2-3 working days that's all. There is a certificate of the product's quality shown on the site too.
http://www.bulknutrition.com/?products_id=1506
http://www.bulknutrition.com/?products_id=1802
This tastes like the Inositol in the capsules from Holland and Barrett pretty much like icing sugar, and Inositol is quite similar to the glucose molecule I think. It's the real deal as far as I'm concerned. There are a couple of user reviews too and a decent forum.
Posted by Meri-Tuuli on May 31, 2006, at 10:38:11
In reply to Re: inositol questions, posted by nolvas on May 31, 2006, at 6:19:41
Hey there nolvas again,
Thanks for the info. I might just go with h+b (which, BTW, I'm not particulary fond off!) coz £35 is too much for me at the moment, even if you get 1kg!!! Actually, I'm seeing a nutritionist who specilises in mental disorders, so I'll see what she says. I met her at an depression alliance meeting - she was giving a free talk. So we'll see....
Kind regards
Meri
Posted by nolvas on May 31, 2006, at 11:08:49
In reply to Re: inositol questions » nolvas, posted by Meri-Tuuli on May 31, 2006, at 10:38:11
Ok well check my links again because I posted a link for 200 grams in there which is only $5.99, you still have to pay around $35 for shipping, so I reckon it will cost you about £17 or so. Still a very good price for 200 grams powder :)
Posted by Meri-Tuuli on June 1, 2006, at 9:14:49
In reply to Re: inositol questions, posted by nolvas on May 31, 2006, at 11:08:49
hey there
Sorry Nolvas I didn't mean to offend you, I checked the links out but unfortunately (and generally) I don't even bother with American websites because I don't have a credit card (only a switch card) and they usually ask for a credit card payment. So I don't bother with American sites.
But thanks for the advice anyway!!! But you're right the 200g bottle is good value.
Kind regardsMeri
Posted by honeybee on June 1, 2006, at 15:44:13
In reply to Re: inositol questions, posted by Meri-Tuuli on June 1, 2006, at 9:14:49
What exactly is inositol? I seem to understand that it increases the sensitivity of the serotonin receptors but is this targeted to the brain or serotonin receptors all over the body?
hb
Posted by nolvas on June 1, 2006, at 21:42:25
In reply to Re: inositol questions, posted by Meri-Tuuli on June 1, 2006, at 9:14:49
Ah no I wasn't offended :)
Inositol description >
http://en.wikipedia.org/wiki/Inositol
Posted by honeybee on June 6, 2006, at 8:34:54
In reply to Re: inositol questions, posted by nolvas on June 1, 2006, at 21:42:25
What's its safety and efficacy profile? I imagine that I take it as part of my B-vitamin complex, but it seems like it's the kind of thing that needs to be taken stand alone?
Thanks, all.
hb
Posted by Larry Hoover on June 6, 2006, at 11:43:09
In reply to silly question? Re: inositol questions, posted by honeybee on June 1, 2006, at 15:44:13
> What exactly is inositol?
It is a simple sugar. A hexose. http://en.wikipedia.org/wiki/Inositol It's hard to picture, if you haven't seen the molecule in three dimensions, but it is not flat. It looks like a ring, because it's hard to draw any other way, but it is a lumpy bent ring, with a specific conformation. cis-1,2,3,5-trans-4,6-cyclohexanehexol. Every carbon on the ring has an oxygen/hydrogen pair (hydroxyl group) stuck to it. That means each carbon can react to link to other molecules (via the oxygen), to form larger molecules still. If you look at the wiki drawing, the dashed lines indicate you're to picture the atoms as being below the plane of the drawing. Those solid wedges indicate bonds above the plane.
A hydroxyl group "means" something (C-H bonds generally don't mean anything), and *that* meaning gets modified if there's a phosphate stuck on it. The language is the structure itself. So, the body speaks in lumpy molecules. Kind of like sign language.
Most often, inositol gets phosphate groups stuck onto it. One phosphate group turns it into myo-inositol. Three phosphate groups makes it into inositol triphosphate (ITP), which is a direct modulator of serotonergic synapses. It is quite probable that free inositol does something similar. It doesn't much matter, as there are enzymes just itching to glue on those phosphate groups. Free inositol/myo-inositol is just a raw material to those enzymes.
Six phosphate groups turns it into phytic acid, http://en.wikipedia.org/wiki/Inositol_hexaphosphate, which is not digestible by humans. It stays all phosphated, and that makes it a strong chelator for minerals. If you get too much phytate in your diet (e.g. from bran), then you can end up with high mineral poop, instead of the intended uptake of those minerals.
> I seem to understand that it increases the sensitivity of the serotonin receptors but is this targeted to the brain or serotonin receptors all over the body?
>
> hbUnless there is direct evidence otherwise (which I have never seen), one should assume systemic effects. Different serotonin receptor subtypes themselves lead to a diversity of effects, so it is really hard to predict how it will affect anybody. Gotta do the experiment, eh?
Lar
Posted by honeybee on June 6, 2006, at 12:06:37
In reply to Re: silly question? Re: inositol questions » honeybee, posted by Larry Hoover on June 6, 2006, at 11:43:09
Larry, As ever, your encyclopedic knowledge humbles me. It's true, I may give Inositol a try, but only after I get a sense of whether or not I'll participate in this TMS study (meeting with people today!). Fingers crossed.
One more question for you, though. Are scientists/pharmaceutical companies trying to mitigate or reduce the systemic effects of SSRIs (or something like Inositol)? Not that doing so would necessarily solve all the problems psych meds cause, but it would seem to go a long way to improving drug tolerance.
Oh, and did you try it, does it work for you, Larry?
hb
Posted by nolvas on June 18, 2006, at 5:27:18
In reply to Re: inositol questions, posted by Meri-Tuuli on June 1, 2006, at 9:14:49
I've just got some good news.
http://www.myprotein.co.uk/ where I buy whey protein from has started selling Inositol powder for £3.99 per 100g. So you can buy as much or as little as you like (min 100g). Excellent news!I looked up the price for 1KG and they give you a 25% discount so it comes to £29.93, making it cheaper than buying from the USA.
This is the end of the thread.
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