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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by kiwiredbeach on November 9, 2006, at 4:12:00
As one of the less educated members of the forum could someone explain the differences between MOA and COMT. I know that there different chemicals but dont they do the same thing ..ie break down neurotransmitters
Why do we need two different chemicals and do they work in different parts of the brain
Posted by linkadge on November 9, 2006, at 8:36:08
In reply to MOA and COMT, posted by kiwiredbeach on November 9, 2006, at 4:12:00
The thing is that they don't break down the same cluster of neurotransmitters.
MAO-A generally responsable for the breakdown of
Ser,nor,dop,and some trace amines.
COMT Just norepinephrine, (and dopamine?)Anyhow, none of the metabilolic pathways, ie MAO-A,B, SERT,NET,DAT,COMT etc, fully overlap with another.
They often work to compensate for eachother.
Ie. if DAT was solely responsable for the metabolism of dopamine, then a dat inhibitor would result in dopamine overflow. Instead, other pathways can take over so as to prevent neurotoxicity.Linkadge
Posted by kiwiredbeach on November 9, 2006, at 9:24:55
In reply to Re: MOA and COMT, posted by linkadge on November 9, 2006, at 8:36:08
Thanks Linkadge
I now know a little more, gee I thought there was just comt and moa, and there's more gee god made the body complicated...sigh
Clive
Posted by qqqsimmons on November 9, 2006, at 11:50:00
In reply to Re: MOA and COMT, posted by kiwiredbeach on November 9, 2006, at 9:24:55
thanks linkadge. more to look up.
I said before that a study showed fish oil was an MAO inhibitor. I should've said it inhibited MAO-B only. MAO-B breaks down dopamine and phenethylamine but not serotonin, epinephrine and norepinephrine.
just in case anyone didn't catch this yet: another study did show fish oil increased serotonin (5-HT) and dopamine, but not norepinephrine in rats' hippocampi.
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Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats][Article in Chinese]
Li H, Liu D, Zhang E.
Department of Child and Adolescent Health, Shanxi Medical University, Taiyuan 030001, China.In order to observe the change of brain fatty acid composition and neurotransmitter by DHA supplementation during the development stage of young rats, pregnant rats were randomly divided into four groups: normal control group (O), low (L), medium (M) and high (H) dose-DHA supplemented groups. The fatty acids composition, the levels of 5-hydroxy-tryptamine (5-HT), dopamine (DA), norepinephrine (NE) and somatostatin (SS) in ceretral cortex and hippocampus of offsprings were measured. The body weight of pregnant rats and offsprings were also observed. The results showed that DHA content of brain homogenate and the levels of 5-HT, DA and SS in hippocampus of experimental young rats were significantly higher than those of the control group. And the body weight of young rats in the three DHA-supplemented groups were retarded in different degree. It was concluded that DHA supplementation changed the fatty acid composition and increased the levels of 5-HT, DA and SS in hippocampus. Proper ratio of n-3 and n-6 fatty acids in dietary supplementation should be considered.
Posted by linkadge on November 10, 2006, at 9:00:40
In reply to Re: MOA-B, fish oil, posted by qqqsimmons on November 9, 2006, at 11:50:00
I had heard that fish oil affected neurotransmitter levels, but never heard that it affected monoamine oxidase levels.
Linkadge
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