Psycho-Babble Alternative Thread 742858

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How much b6 is safe?

Posted by linkadge on March 21, 2007, at 13:46:59

How much vitamin b6 is safe to ingest on a daily basis? It really helps my anxiety, in combination with theanine.

Linkadge

Re: How much b6 is safe?

Posted by qqqsimmons on March 22, 2007, at 8:37:01

In reply to How much b6 is safe?, posted by linkadge on March 21, 2007, at 13:46:59

fyi, excessive doses of b6 may affect male reproductive system:

check pubmed for:
Effects of megadoses of pyridoxine on spermatogenesis and male reproductive organs in rats

Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives

Re: How much b6 is safe? » linkadge

Posted by Larry Hoover on March 24, 2007, at 14:24:03

In reply to How much b6 is safe?, posted by linkadge on March 21, 2007, at 13:46:59

> How much vitamin b6 is safe to ingest on a daily basis? It really helps my anxiety, in combination with theanine.
>
> Linkadge

You might be interested in this thread: http://www.dr-bob.org/babble/alter/20070201/msgs/736058.html

1,000 mg/day is where I'd set the safe upper limit. If side effects do occur, they're reversible on discontinuation.

Lar

Re: How much b6 is safe? » qqqsimmons

Posted by Larry Hoover on March 24, 2007, at 14:30:52

In reply to Re: How much b6 is safe?, posted by qqqsimmons on March 22, 2007, at 8:37:01

> fyi, excessive doses of b6 may affect male reproductive system:
>
> check pubmed for:

Always appreciate the heads-up.

> Effects of megadoses of pyridoxine on spermatogenesis and male reproductive organs in rats

Woi! Those rats were sure seriously megadosed.....up to 1000 mg/kg body weight. Even the lower of the two doses which showed no adverse effects (i.e. 125 and 250 mg/kg) is nearly 10 times what I've been suggesting.

> Androgen hydroxysteroid dehydrogenases under the influence of pyridoxine derivatives
>

This latter paper is more about the regulatory differences between pyridoxine and pyridoxal, which seem to be opposed to one another. That's pretty commonplace, actually, where a precursor (pyridoxine) activates, and a downstream product suppresses some biological function. I don't think it's about megadoses at all.

Thanks again.

Lar

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