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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on June 2, 2007, at 14:31:31
Is there any research to support the hypotensive effect of hawthorn?
I have borderline high blood pressure, and my doc doesn't want to put me on antihypertensives due to the other meds I am on, and due borderline nature of my blood pressure.
Thanks
Linkadge
Posted by KayeBaby on June 5, 2007, at 1:30:48
In reply to hawthorn - any research ?, posted by linkadge on June 2, 2007, at 14:31:31
Best I can remember is the research became conflicting. but......
I have had luck with suggesting it for a few people. My father being one. He took it for a month and it came down enough to get his DR. off his back. Cal/mag and potassium brings mine down noticably.
Celery is supposed to be great in some people. 4 ribs a day.
There is also and East India indian her-I will have to look it up...but it has been getting raves.
Take Care,
Kaye
Posted by nolvas on June 10, 2007, at 7:31:36
In reply to hawthorn - any research ?, posted by linkadge on June 2, 2007, at 14:31:31
Hawthorn may help to lower Blood Pressure in Hypertension patients (by dilating the Blood Vessels, by inhibiting Angiotensin-Converting Enzyme (ACE), by functioning as a diuretic and by enhancing Heart function).
Abdul-Ghani, A. S., et al. Hypotensive effect of Crataegus oxyacantha. Int J Crude Drug Res. 25:216-220, 1987.
· Ammon, H. P. T., et al. Crataegus, toxicology and pharmacology. I. Toxicity. Planta Medica. 43:105-120, 1981.
· Graham, J. D. P. Crataegus oxycantha in hypertension. British Medical Journal. 11:951-953, 1939.
· Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
Hawthorn has been demonstrated to exert a mild blood pressure-lowering effect. It can take up to four weeks for these effects to tale full effect.
· Leuchtgens, H. Crataegus special extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study. Fortschr Med. 111(20-21):352-354, 1993.
In 30 patients with stage NYHA II cardiac insufficiency, a placebo-controlled randomized double-blind study was carried out to determine the efficacy of the Crataegus special extract WS 1442. Treatment duration was 8 weeks, and the substance was administered at a dose of 1 capsule taken twice a day. The main target parameters were alteration in the pressure-x-rate product (PRP) under standardised loading on a bicycle ergometer, and a score of subjective improvement of complaints elicited by a questionnaire. Secondary parameters were exercise tolerance and the change in heart rate and arterial blood pressure. The active substance group showed a statistically significant advantage over placebo in terms of changes in PRP (at a load of 50 W) and the score, but also in the secondary parameter heart rate. In both groups, systolic and diastolic blood pressure was mildly reduced. No adverse reactions occurred.
· Miller, A. L. Botanical influences on cardiovascular disease. Alt Med Rev. 3(6):422-431, 1998.
Crataegus oxycantha has been used traditionally as a cardiac tonic and current uses include the treatment of hypertension.
· Petkov, V. Plants with hypotensive, antiatheromatous and coronary dilating action. American Journal of Chinese Medicine. 7:197-236, 1979.
· Schussler, M., et al. Myocardial effects of flavonoids from Crataegus species. Arzneimittelforschung. 45(8):842-845, 1995.
The influence of the main flavonoids from Crataegus species (hawthorn, Rosaceae) on coronary flow, heart rate and left ventricular pressure as well as on the velocity of contraction and relaxation was investigated in Langendorff perfused isolated guinea pig hearts at a constant pressure of 70 cmH2O. Drug action was evaluated in a concentration range of 10(-7) to 5 x 10(-4) mol/l. An increase of coronary flow caused by the O-glycosides luteolin-7-glucoside (186%), hyperoside (66%) and rutin (66%) as well as an increase of the relaxation velocity (positive lusitropism) by luteolin-7-glucoside (104%), hyperoside (62%) and rutin (73%) were the major effects observed at a maximum concentration of 0.5 mmol/l. Furthermore, slight positive inotropic effects and a rise in heart rate were seen. Similar but less intensive actions were found with the C-glycosides vitexin, vitexin-rhamnoside and monoacetyl-vitexin-rhamnoside. Possible beta-
adrenergic activities of the flavonoids could be excluded by the addition of propranolol in fixed concentrations of 10(-8) to 10(-5) mol/l. Moreover, pretreatment of the animals with reserpine (7 mg/kg) did not influence myocardial activity of hyperoside (10(-4) mol/l). As previous experiments showed an inhibition of the 3',5'-cyclic adenosine monophosphate phosphodiesterase, the results suggest an inhibition of this enzyme as the possible underlying mechanism of cardiac action of flavonoids from Crataegus species.· Walker, A. F., et al. Promising hypotensive effect of hawthorn extract: A randomized double-blind pilot study of mild, essential hypertension. Phytotherapy Research. 16(1):48-54, 2002.
This pilot study was aimed at investigating the hypotensive potential of hawthorn extract and magnesium dietary supplements individually and in combination, compared with a placebo. Thirty-
six mildly hypertensive subjects completed the study. At baseline, anthropometric and dietary assessment, as well as blood pressure measurements were taken at rest, after exercise and after a computer stress test. Volunteers were then randomly assigned to a daily supplement for 10 weeks of either: (a) 600 mg Mg, (b) 500 mg hawthorn extract, (c) a combination of (a) and (b), (d) placebo. Measurements were repeated at 5 and 10 weeks of intervention. There was a decline in both systolic and diastolic blood pressure in all treatment groups, including placebo, but ANOVA provided no evidence of difference between treatments. However, factorial contrast analysis in ANOVA showed a promising reduction (p = 0.081) in the resting diastolic blood pressure at week 10 in the 19 subjects who were assigned to the hawthorn extract, compared with the other groups. Furthermore, a trend towards a reduction in anxiety (p = 0.094) was also observed in those taking hawthorn compared with the other groups. These findings warrant further study, particularly in view of the low dose of hawthorn extract used.Laypersons’ Publications
· Murray, Michael T. The Healing Power of Herbs (2nd Edition). Prima Publishing, Rocklin, California, USA. 1993:207.
The author describes Hawthorn’s mild ability to lower blood pressure via various mechanisms and notes that it may require two weeks of hawthorn used before tissue concentrations of hawthorn’s active ingredients are high enough to exert hypotensive actions.
· Stansbury, J. Sidestep heart disease. Nutrition Science News. March 1999.
· Hawthorn: old reliable for the heart. Nutrition Science News. July 2000.
Hawthorn decreases blood pressure.
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