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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by MoparFan91 on May 8, 2009, at 13:24:58
From what I've read,
35% of people with Bipolar Disorder have Undermethylation (Histadelia) as their main biochemical imbalance.
25% of people with Bipolar Disorder have Overmethylation (Histapenia) as their main biochemical imbalance.
18% of people with Bipolar Disorder have Pyroluria as their main biochemical imbalance.
In what ways do you think that Bipolar Disorder manifests itself for each of these three main imbalances?
As we know that one can overlap the other (e.g. Histadelia and Pyroluria), this is provided that the person has only one.
I believe these three imbalances, hence different neurotransmitter imbalances (as these imbalances affect neurotransmitter levels),
explain why not everyone has the same response to a given psychiatric medication or supplement,
and why one person may respond well to a given treatment,
and why another person has disastrous results to that same exact one,
while, for another person, that same given treatment doesn't do anything.Let's take SAM-e or SSRI's, for example.
People with Under-Methylation respond well to these two because they are very low in serotonin and other neurotransmitters; but moreso in serotonin.
On the other hand, people with Over-Methylation have bad reactions to these treatments because they are already high in neurotransmitters; dopamine in particular.
Like under-methylators, pyrolurics also respond well to SSRI's because low serotonin is their main neurotransmitter imbalance, though GABA is possibly another one due to the low Zinc. SAM-e probably has no effect on them.So, as we know from this, not all bipolars get worse with SSRI's or SAM-e at recommended therapeutic doses. Based on this, SAM-e could possibly stabilize around 1/3 of people with bipolar disorder even without a mood stabilizer if undermethylation is their only imbalance. SSRI anti-depressants could help stabilize around 50% of people with bipolar. However, around 20% of them would probably need a mood stabilizer along with the anti-depressant if GABA is also low along with serotonin, which is may be the case of pyrolurics or those who have pyroluria along with the undermethylation/histadelia.
SSRI's and SAM-e would be detrimental for 1/4 of them, causing mania and increased cycling at low or normal therapeutic doses, regardless of whether or not a mood stabilizer is present.
This is concerning the main three imbalances. There are others as well. This means there are 22% of people with bipolar who have neither of these three main ones. It's probably more likely that these bipolar people won't have any response to SSRI's or SAM-e for thee depression part of their condition.
These are just my conclusions.
Posted by nolvas on May 9, 2009, at 2:48:21
In reply to Under/Overmethylation,Pyroluria + Bipolar Disorder, posted by MoparFan91 on May 8, 2009, at 13:24:58
Sorry to refer you to another forum, but this one has a lot of information on the specific conditions you describe :
Posted by Lao Tzu on May 17, 2009, at 9:42:44
In reply to Under/Overmethylation,Pyroluria + Bipolar Disorder, posted by MoparFan91 on May 8, 2009, at 13:24:58
I am diagnosed Bipolar/Schizophrenia and I believe I have pyroluria because I feel more stable on B6 and zinc picolinate. I don't do well on folic acid or B12. In addition, however, I also need vitamins E and C, as well as fish and borage oils. I couldn't tell you if I was over or under-methylated. It's too confusing. But pyroluria, yes, that might be a possibility due to my positive reaction to zinc and P5P (B6). One definite benefit I've noticed from using P5P is that it tends to quell my paranoia, so I believe I definitely need it everyday. Let me note that zinc picolinate is the best form of zinc I've ever used, for anyone out there wishing to try zinc in their regimen.
Posted by Loops on June 9, 2009, at 12:55:18
In reply to Re: Under/Overmethylation,Pyroluria + Bipolar Diso, posted by Lao Tzu on May 17, 2009, at 9:42:44
Lao -
how much zinc do you take a day? I was messing around with different forms - mostly chelated and ended up getting very sick with the flu - which has happened before - possibly due to taking too much although I was careful not to go above 35mg a day. Still - maybe my copper levels are too low now? I doubt it as I still have anxiety/depression problems. CAn't afford to get tested unfortunately.
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