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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Phillipa on September 28, 2010, at 5:23:22
Besides causing spontaneous fx of femurs shoulders etc, now bisphosphinates found to double risk of esophageal cancers. These include fosamax, actonel, bonivia, reclast. Phillipa
Common bone drugs linked to esophageal cancer risk
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By Kate KellandLONDON | Thu Sep 2, 2010 7:09pm EDT
LONDON (Reuters) - People who take a commonly used class of osteoporosis drugs called bisphosphonates for more than five years may be doubling their risk of developing cancer of the gullet or esophagus, a British study found on Friday.
Researchers who conducted the work said the results were worrying, but should not prompt doctors or patients to immediately change their practice on bisphosphonates, which are prescribed mainly to older people to help strengthen weak bones.
"We have to be concerned, but this is the first large study with long-term follow up that has found this effect, and it is just one observational study," said Jane Green of Oxford University's Cancer Epidemiology Unit, whose research was published in the British Medical Journal.
"Also, because esophageal cancer is uncommon, even a doubled risk is still a low risk," she said in a telephone interview.
Bisphosphonates are a class of drug designed to help prevent bone fractures and offset bone weakness associated with menopause and with osteoporosis. They include Merck & Co's Fosamax, Roche's Boniva, Novartis's Reclast and Warner Chilcott's Actonel.
Green and colleagues from Britain's Medicines and Healthcare products Regulatory Agency (MHRA) analyzed data from the UK General Practice Research database on men and women aged over 40 who had either esophageal cancer, stomach cancer or colorectal cancer diagnosed between 1995 and 2005.
They found that people with 10 or more prescriptions for bisphosphonates, or with prescriptions over about five years, had nearly double the risk of esophageal cancer compared with people with no bisphosphonate prescriptions.
"In Europe and North America, the incidence of esophageal cancer at age 60-79 is typically 1 per 1,000 population over five years, and this is estimated to increase to about 2 per 1,000 with five years' use of oral bisphosphonates," they wrote in a report of their findings.
In people who had one or more previous prescriptions for oral bisphosphonates, the risk of developing of esophageal cancer was 30 percent higher than in those who had never taken the drugs. The researchers found no links between bisphosphonate prescriptions and stomach or bowel cancer.
Green noted that a previous study using the same UK database had found no link between bisphosphonates and esophageal cancer, but said her research had tracked patients for almost twice as long. She also said that with populations aging, bone diseases such as osteoporosis were becoming more common, leading to higher levels of bisphosphonate use.
"It's important to see our findings as part of a wider picture. These are very commonly prescribed drugs and we don't have enough information about the long-term risks and benefits."
In a commentary on the study, Diane Wysowski of the U.S. Food and Drug Administration said "the possibility of adverse effects on the esophagus should prompt doctors who prescribe these drugs to consider risks versus benefits."
She also suggested doctors "tell patients to report difficulty in swallowing and throat, chest, or digestive discomfort so that they can be promptly evaluated and possibly advised to discontinue the drug."
Posted by Willful on September 28, 2010, at 5:23:22
In reply to Bisphosphinates Found To Increase Esophageal CA, posted by Phillipa on September 21, 2010, at 0:11:03
Phillipa, would you please stop posting these frightening posts about bisphosphonates.
It's not relevant to this board and it's also not very helpful to people who are taking these drugs-- which is a lot of people.
You may have weighed the pros and cons and decided not to take these, but this is not the decision of LOTS of people and they don't need to read scare stories about these drugs.
Moreover, please post these on the health pages, if you need to post them.
Willful
Posted by Phillipa on September 28, 2010, at 5:23:22
In reply to Re:Please redirect this to health board, posted by Willful on September 22, 2010, at 17:33:15
Fine I will and yes they are scarey as I have osteoporosis. But will not take those meds. Now that the FDA has issued warnings I know I made the right decision for me. Phillipa
Posted by Phillipa on September 28, 2010, at 5:23:23
In reply to Re:Please redirect this to health board, posted by Willful on September 22, 2010, at 17:33:15
Willful a good resourse is the National Osteoporosis Site It has a great newsletter and discussion board. Currently there also lawsuits for the spontaneous fractures of femurs, shoulders, and it's real. Please there are other options to these meds. Just like atypical antipsychotics can cause diabetes biophospinates can cause stuff you should know. I believe in being a well informed consumer. It was my ob-gyn that told me about the femur fractures and advised against them. Phillipa
Posted by Phillipa on September 28, 2010, at 5:23:23
In reply to Re:Please redirect this to health board » Willful, posted by Phillipa on September 22, 2010, at 21:20:38
Here is the link to the site. Informed consumers of all products or medications are what we should be in my opinion. Phillipa
http://www.inspire.com/groups/national-osteoporosis-foundation/
This is the end of the thread.
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