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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Jean brady on March 7, 2011, at 16:07:47
I JUST discontinued Prestiq, I have never been so sick with a medication. Talk about anger !!! I was way freaked out and out of control !! As where my friends, family and pets. I am usually mild mannered and do not have a nasty temper..3 weeks into the treatment...I was showing signs of irritability, then POW...yelling at everyone, not taking care of myself or my home..feeling resentment for everything PAST and present. Whew..glad to be back on trusty Cymbalta...although with Cymbalta I can't seem to break through that glass depression ceiling..so I just have to deal with it...BYE BYE Prestiq...horrible poison, lucky not to have been hospitalized, wish I could sue!!!
Posted by bearfan on March 8, 2011, at 21:00:35
In reply to Prestiq vs Cymbalta, posted by Jean brady on March 7, 2011, at 16:07:47
Cymbalta has its own crappy side effects...
Posted by Conundrum on March 21, 2011, at 13:59:31
In reply to Prestiq vs Cymbalta, posted by Jean brady on March 7, 2011, at 16:07:47
I found pristiq to be slightly better than Pristiq, although not a miracle drug. I'm on Cymbalta now and it doesn't seem to do anything, except messing w/ my bowels and causing male problems. Pristiq actually helped in that area.
Posted by mtdewcmu on April 19, 2011, at 15:46:36
In reply to Re: Prestiq vs Cymbalta » Jean brady, posted by Conundrum on March 21, 2011, at 13:59:31
> I found pristiq to be slightly better than Pristiq, although not a miracle drug.
There have been no miracle drugs in psychiatry since thorazine and lithium in the 1950s.
> I'm on Cymbalta now and it doesn't seem to do anything, except messing w/ my bowels and causing male problems. Pristiq actually helped in that area.
I grew to hate Paxil due to the bowel issues. Needless to say, I chose a different drug.
It seems like the jury is still out on the merits of hitting norepinephrine as a treatment for depression. None of the specific NE reuptake inhibitors have even come close in efficacy to SSRIs and older drugs. So, until someone can persuade me otherwise, I will believe that SNRIs are just SSRIs with more side effects.
You might think Effexor is a counterexample, in that it affects both 5-ht and NE and is as good of an AD as anything else. But venlafaxine itself operates mostly on 5-ht. Only the active metabolite has significant effects on NE. So, my gut feeling is that Effexor's effectiveness stems almost entirely from its SSRI-like properties.
Posted by James H on April 29, 2011, at 16:58:15
In reply to Re: Prestiq vs Cymbalta » Conundrum, posted by mtdewcmu on April 19, 2011, at 15:46:36
> There have been no miracle drugs in psychiatry since thorazine and lithium in the 1950s.
>I would argue one more: isocarboxid, the original antidepressent and MAOI. :)
Posted by desolationrower on May 1, 2011, at 17:36:21
In reply to Re: Prestiq vs Cymbalta » Conundrum, posted by mtdewcmu on April 19, 2011, at 15:46:36
> > I found pristiq to be slightly better than Pristiq, although not a miracle drug.
>
> There have been no miracle drugs in psychiatry since thorazine and lithium in the 1950s.
>
> > I'm on Cymbalta now and it doesn't seem to do anything, except messing w/ my bowels and causing male problems. Pristiq actually helped in that area.
>
> I grew to hate Paxil due to the bowel issues. Needless to say, I chose a different drug.
>
> It seems like the jury is still out on the merits of hitting norepinephrine as a treatment for depression. None of the specific NE reuptake inhibitors have even come close in efficacy to SSRIs and older drugs. So, until someone can persuade me otherwise, I will believe that SNRIs are just SSRIs with more side effects.
>
> You might think Effexor is a counterexample, in that it affects both 5-ht and NE and is as good of an AD as anything else. But venlafaxine itself operates mostly on 5-ht. Only the active metabolite has significant effects on NE. So, my gut feeling is that Effexor's effectiveness stems almost entirely from its SSRI-like properties.i'm not sure what you're on about since many 'old drugs' aka tcas are mainly NRIs.
-d/r
Posted by mtdewcmu on May 2, 2011, at 0:10:32
In reply to Re: Prestiq vs Cymbalta, posted by desolationrower on May 1, 2011, at 17:36:21
> > > I found pristiq to be slightly better than Pristiq, although not a miracle drug.
> >
> > There have been no miracle drugs in psychiatry since thorazine and lithium in the 1950s.
> >
> > > I'm on Cymbalta now and it doesn't seem to do anything, except messing w/ my bowels and causing male problems. Pristiq actually helped in that area.
> >
> > I grew to hate Paxil due to the bowel issues. Needless to say, I chose a different drug.
> >
> > It seems like the jury is still out on the merits of hitting norepinephrine as a treatment for depression. None of the specific NE reuptake inhibitors have even come close in efficacy to SSRIs and older drugs. So, until someone can persuade me otherwise, I will believe that SNRIs are just SSRIs with more side effects.
> >
> > You might think Effexor is a counterexample, in that it affects both 5-ht and NE and is as good of an AD as anything else. But venlafaxine itself operates mostly on 5-ht. Only the active metabolite has significant effects on NE. So, my gut feeling is that Effexor's effectiveness stems almost entirely from its SSRI-like properties.
>
> i'm not sure what you're on about since many 'old drugs' aka tcas are mainly NRIs.
>
> -d/rThat is a curious fact that some TCAs are basically NRIs and yet are considered effective. Are there any recent studies on them, though? The TCAs that are still used in studies seem to be the ones that affect 5-ht. And these drugs are more complicated than we give them credit for. Who knows why drugs like Reboxetine largely failed as ADs and some apparently similar ones succeeded? I don't pretend to know.
Posted by desolationrower on May 3, 2011, at 23:43:31
In reply to Re: Prestiq vs Cymbalta » desolationrower, posted by mtdewcmu on May 2, 2011, at 0:10:32
I think it has to do with drugs not being very effective, so many studies come up with no benefit. Proving a drug works has a lot to do with luck i think.
I do think dirtier drugs will have marginal efficacy advantages, although that has to be weighed against greater side effects.
-d/r
This is the end of the thread.
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