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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Kari on September 2, 2002, at 15:22:07
Hi everyone,
Just wondering how one might explain the fact that Remeron has a sedating effect and has been considered for treatment of schizophrenia when it enhances noradrenergic activity as well as serotonergic. Never tried it, but what I have heard about this drug sounds contradictory.
Kari.
Posted by sleepy lizard on September 2, 2002, at 19:47:12
In reply to Remeron, posted by Kari on September 2, 2002, at 15:22:07
Check out www.preskorn.com for detailed research on antidepressants. Mitrazapine (Remeron) does effect serotonin (5-HT-2A and 2C) and norepinephrine alpha-2 receptor blockade, but also other receptors like H1 histamine. The histamine increase is responsible for the sedation at low doses (15 mg). At higher doses (30 mg and up) the sedation is partly overcome by the norepinephrine increase. This particular drug changes profile a lot with the dosage. Does this help any?
Posted by Kari on September 3, 2002, at 15:07:58
In reply to Re: Remeron » Kari, posted by sleepy lizard on September 2, 2002, at 19:47:12
>Check out www.preskorn.com for detailed research on antidepressants. Mitrazapine (Remeron) does effect serotonin (5-HT-2A and 2C) and norepinephrine alpha-2 receptor blockade, but also other receptors like H1 histamine. The histamine increase is responsible for the sedation at low doses (15 mg). At higher doses (30 mg and up) the sedation is partly overcome by the norepinephrine increase. This particular drug changes profile a lot with the dosage. Does this help any?>>
Thank you for this information.
This is the end of the thread.
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