Posted by Elizabeth on September 15, 1999, at 2:03:03
In reply to High Dose Selegiline (Deprenyl) for Social Phobia?, posted by John on September 9, 1999, at 12:10:53
I didn't find selegiline at all helpful for depression or anxiety, though I did great on phenelzine (until it pooped out...grr). It didn't make me tired; it worsened my insomnia. It also killed what little appetite I had, and I think it might have worsened my anxiety.
One difference between the two drugs is that selegiline won't cause increased levels of GABA in the brain (as phenelzine does) because selegiline isn't related to hydrazine.
Also, the amphetamines that are metabolites of selegiline are l-amphetamine and l-methamphetamine, which aren't the isomers considered to be beneficial to mood and attention; the l- optical isomers are thought to be more responsible for side effects in the periphery. (Dexedrine = d-amphetamine)
I think I remember the study you're talking about on moclobemide. Moclobemide generally seems to have a reputation as a poor antidepressant that will occasionally work for somebody who hasn't responded to other things.
FWIW, Parnate helps somewhat with anxiety (though not as much as Nardil did), doesn't cause weight gain (in general), and (at least for me) doesn't cause sexual dysfunction (caveat: I don't seem to get sexual dysfunction on antidepressants much at all - I was fine on Prozac too, e.g.).
poster:Elizabeth
thread:11298
URL: http://www.dr-bob.org/babble/19990914/msgs/11590.html