Posted by Elizabeth on July 7, 1999, at 22:26:05
In reply to One More "?" About Selegiline , posted by Judy on July 5, 1999, at 9:34:29
> I'm not sure I understand why the MAOI bypassing the GI tract avoids the tyramine problem. The MAOI is still very much in your system. Does it actually have to interact with the tyramine *in* the GI tract to cause trouble?
Well, here's the thing, if the MAOI doesn't get into the upper GI tract, then there will still be MAO living there peacefully. Thus, oral tyramine doesn't have a chance to get into the blood, and thereby the brain, because it is metabolized normally.
With drug-drug interactions it's generally a more complicated matter, as the drugs in question aren't metabolized by MAO as such, but rather, they have pharmacodynamic interactions in the CNS. (Although transdermal MAOIs would presumably have no potentiating effect on oral dimethyltryptamine and derivatives - this is normally considered a beneficial interaction, though.)
> Elizabeth, please take this with the humor I intend it: If I read once more about your not having sex problems with all these different meds, I'm may freak and track you down and slap you silly out of my envy and frustration!!!! (Did I read in one of your posts that you're in the Boston area? I'm on the South Shore - about 20 miles south, so I might just be able to find you!) How the heck to you pull that off?!?!?! Of course, with all the other side effects you're suffering, it's probably not the magical experience for you that I'm imagining.
I wouldn't call it "magical," no! Anyway, I'm not yet in my sexual prime, so to speak, so don't think that sexual bliss comes easily to me even unmedicated! (Was that more information than you needed? :-) I do feel for people who get this disheartening side effect; unlike some other side effects, it's very difficult to deal with, although some pharmacologic add-ons seem to work some of the time (yohimbine, bupropion, sildenafil, etc.). There's also the old "slip some Prozac in your partner's coffee so it takes him forever too" trick. Not that I'm suggesting such a thing. ;-)
poster:Elizabeth
thread:5905
URL: http://www.dr-bob.org/babble/19991001/msgs/8410.html