Posted by Rick on November 18, 1999, at 1:17:12
In reply to Buspar - "partial" agonist?, posted by Scott L. Schofield on November 17, 1999, at 11:42:07
The following site addresses your questions and related issues. This is a page from the middle of the presentation, but the bullet point at the end is particularly pertinent (...and surprising: it suggests that a Buspar/pindolol combination has a potent and rapid-onset antidepressant effect).
Rick
http://www.med.nyu.edu/Psych/aug/sld035.htm
> I often see buspirone (Buspar) described as being a "partial" agonist at 5-HT1a receptor sites.
>
> 1. What does "partial" mean?
> (pre-synaptic vs post-synaptic?)
>
> 2. As an agonist, wouldn't it work against the antagonist activity of pindolol?
>
>
> Thanks.
>
> Scott
poster:Rick
thread:15384
URL: http://www.dr-bob.org/babble/19991108/msgs/15432.html