Re: Naltrexone....but how?

Posted by JohnL on February 22, 2000, at 5:11:02

In reply to Naltrexone....but how?, posted by Bruce on February 21, 2000, at 19:52:03

> Can someone explain to me in educated layman's terms how
> Naltrexone helps depression? It is an opiate antagonist I know,
> but how does this help depression?
>
> Thanks in advance,
>
> Bruce
I've asked pdocs this very same question. They don't know. They assume there is some link between the serotonin-opioid-dopamine systems. My own personal theory is that Naltrexone stimulates increased production of endorphines (feel-good hormones, similar to a runner's high). Much the same as when Remeron blocks certain serotonin receptors, it stimulates increased sertonin production. Antagonists often block the feedback mechanism and basically open the spigot on neurotransmitter production. Does Naltrexone work this way? Heck if I know. Just a guess.

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Naltrexone....but how? Bruce 2/21/00
Re: Naltrexone....but how? jd 2/21/00
Re: Naltrexone....but how? JohnL 2/22/00
Re: Naltrexone....but how? Will 2/26/00
Re: Naltrexone....but how? ChrisK 2/27/00

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