Posted by AndrewB on March 6, 2000, at 22:20:17
In reply to Re: Pivagabine, posted by Brad H on March 6, 2000, at 18:49:44
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> > Why are you looking for a CRH antagonist drug? Do you have specific symptoms that you think such a drug may help with?
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> I have an agitated depression. CRF antagonist drugs are being studied for both anxiety and depression. Also I have started noticing a decline in my short term memory and recall. I believe this is happen fromt he excess cortisol running through my body, which can have some detrimental effects on the hypothalamus, etc. So I believe that the CRF antagonist might help control these symptoms. Thanks for all the info......BradBrad,
Apparently hypercotisolism and hyperactivity of the HPA axis is associated with depression, particulary depression with anxiety. Elevated cortisol can damage serotonin transmission via the hippocampus thus causing depression. Cortisol reducers have been shown to alleviate depression by restoring HPA axis normalcy. On the other hand, ADs have been shown to normalize the HPA axis and lower cortisol levels, it is a two way street.
This means you don’t have to wait for a CRF antagonist to restore normalcy to your HPA axis. An effective AD can do that for you. Also you can try a cortisol reducer. The anticonvulsant phenytoin (Dilatin) reduces cortisol levels. Brandon, a fellow poster, says Dilatin has relieved his depression and anxiety (See a post of his under the string ’Tianeptine’.). It is mostly side effect free (gum overgrowth can be a problem). It is cheap and can be bought over the internet without a prescription.
Dilatin has also been shown to protect the hippocampus, the part of the brain most vulnerable to atrophy and neuronal death due to the stress hormones. The hippocampus is vitally important to memory- damage to it does cause memory problems! Another substance that can protect the hippocampus is 7-Keto DHEA. This form of DHEA does not convert to sex hormones and seems to be side effect free. 7- Keto is a supplement and can be ordered over the internet also.
Wishing you the best of health,
AndrewB
poster:AndrewB
thread:23593
URL: http://www.dr-bob.org/babble/20000302/msgs/26184.html