Posted by AndrewB on March 17, 2000, at 11:40:54
In reply to Amisulpride w/ Stimulant (anyone?), posted by Ant-Rock on March 16, 2000, at 18:08:23
Anthony,
What a strange story. It’s so weird Amoxapine would do that. After looking up some info. on Amoxapine I think I understand why you are trying amisulpride. Amoxapine is a tricyclic with dopamine receptor blocking activity and amisulpride acts sort of opposite to that. Best of luck with the amisulpride, I hope it works for you as well as it has for me.
There are no drug interactions listed for amisulpride. It can be combined safely with dopamine activating and NE activating meds. Therefore it is my guess that amisulpride can be combined with a stimulant. What I would do however is to take amisulpride for a 5 to 7 days alone so you can evaluate its effects. Then add a small amount of Ritalin to it and go up in dosage from there watching for any reactions.
As far as the borderline low cortisol goes, it brings a lot of questions to my mind. Low cortisol is associated with atypical depression, chronic fatigue syndrome (CFS), adrenal dysfunction and other conditions that have fatigue as a symptom. Possibly these various conditions have a common locality for the perception of fatigue. It seems that hypofunction of the D2-D3 receptors may be responsible for the perception of fatigue in at least some of those with CFS and atypical depression. I would be curious to know whether atypicals who are relieved of depression by an AD find their low cortisol levels have normalized, much as ‘normal’ depressives tend to have their high cortisol levels normalize with successful AD treatment. I’ve also wondered how effective the various purported treatments for adrenal dysfunction, such as hydrocortisone and licorice root, really are in treating fatigue and if they also might be able to make a dent in atypical depression.
I am very interested in how this goes for you. Please keep us informed.
AndrewB
poster:AndrewB
thread:27223
URL: http://www.dr-bob.org/babble/20000312/msgs/27336.html