Posted by michael on March 17, 2000, at 14:20:42
In reply to Re: Educated Guess?/Poop Out, posted by AndrewB on March 16, 2000, at 10:58:16
> A couple comments I wanted to add here.......
>
> SSRI poop out can also be caused by dopamine depletion. For more info. see Dr. Bob's Tips section. Signs to look for in dopamine depletion are: fatigue, mental fatigue (poor memory, poor concentration), sleepiness, apathy, anhedonia. Remedies include dopamine activity enhancers, ideally D2-D3 receptor enhancers, such as the amino acid dopamine precurosor Tyrosine, the D2 agonist Bromocryptine, amisulpride and Mirapex.
>
> Scott, it's my impression also that Wellbutrin has mainly NE activity. I have tried or am using Wellbutrin, Reboxetine, amineptine , Mirapex, and amisulpride so I should be able to tell the difference between NE and dopamine action. I've read contradicting info. on Wellbutrin's supposed dopamine effects so maybe academia is not in agreement on what Wellbutrin actually acts on (and to what degree). By the way Scott, thank you for your imformative (and entertaining) posts, I've learned a lot from you over the months.
>
> Final note, I've been on the combo of amisulpride and Mirapex (also take reboxetine) for 10 days. Good effect, all of amisulpride's effects have been enhanced; euthymia, the anxiolytic effect, the motivation and energy. Too early to tell if this will work long term though, as you noted a while back Scott, dopamine agonists may tend to poop out. Amisulpride and Mirapex are the combination of a presynaptic D2-D3 antagonist with a (postsynaptic) D2-D3 agonist. I guess this enhances dopaminergic activity sort of like plugging the dike and filling the pond.
>
> AndrewB
Hey Andrew,I was just wondering if you're in the US, and also if you've got a doc who's willing to work with you, w/respect to these different meds? Or if you're striking out, somewhat, on your own?
Sounds like you're making some pretty good progress. It seems to me like serotonin gets a lot more focus than dopamine. However, it seems like the dopamine connection might be more relevent, or at least as relevent, in terms of looking at the fatigue aspects, and dysthymia... Especially if these meds give doc's alternatives to explore that possibility, w/o resorting to the dreaded stimulants (please excuse the sarcasm).
Thanks for all the feedback, and info.
michael
poster:michael
thread:26793
URL: http://www.dr-bob.org/babble/20000312/msgs/27352.html