Posted by Cam W. on April 2, 2000, at 12:06:15
In reply to celexa and ultram, posted by jane on April 2, 2000, at 11:01:26
Jane - Your pharmacist may have extrapolated some of this information from another SSRI - Prozac. Prozac is thought to have caused serotonin syndrome in a person taking Ultram. This is possible because Prozac is a potent inhibitor of the same enzyme system that metabolizes Ultram (CYP-2D6 - for the techies). This means that the Prozac will increase the level of Ultram in your bloodstream. Since Ultram can cause seizures, increased blood levels may increase the risk of these seizures. This scenario is when taking Prozac. Celexa also inhibits CYP-2D6, but to such a small extent that it probably could be considered insignificant.Since you have been taking this combination for a year, the chances of developing seizures on this combination is minimal. Do bring it up the next time you see your doctor, but I think this pharmacist was being overly cautious.
*Caveat* - Ultram is not sold in Canada, and I have no personal experience with it. The above information is book knowledge. Get a second opinion before trusting my info. Sincerely - Cam W.
poster:Cam W.
thread:28702
URL: http://www.dr-bob.org/babble/20000401/msgs/28703.html