Posted by sean on April 16, 2000, at 16:36:26
In reply to Re: Neurotoxicity - SSRI's may not be so benign..., posted by saint james on April 15, 2000, at 16:48:41
> >
> > > James here...
> > >
> > > If you use this logic then humans have been on sertonin agents since the 1950's (imiprimine, TCA's) with no problems.
> > >
> > > james
> >
> > james -
> >
> > i may be totally wrong on this, but i was under
> > the impression that the serotonin effects of TCA's
> > (except for amitriptyline) was very small in terms of
> > ratio to norepinephrine.
>
>
> James here....
>
> Correct, you are wrong. TCA's effect serotonin for the most part, thus accounting for the high rate of sucess. Some do have more of a nor-e effect than others. I know them well as my mood only responds to meds that effect nor-e, but most people need meds that effect 5-HT.
>
> jameswell, I did some homework on this and TCA's and
SRI's bind different locations of the serotonin
neurons. both increase net serotonin transmission
but by different means. historical use of tricyclics
may not be indicative of chronic use of SRI's.still takin' my meds in any case!
sean
poster:sean
thread:29745
URL: http://www.dr-bob.org/babble/20000411/msgs/30236.html