Posted by allisonm on April 23, 2000, at 16:05:03
In reply to Re: most sedating a-d's, posted by paul on April 22, 2000, at 23:36:56
> is remeron an a.d.?
Yes.
Go here: http://www.rxlist.com/cgi/generic/mirtaz.htm
REMERON® (mirtazapine) Tablets are an antidepressant for oral administration. Mirtazapine has a tetracyclic chemical structure
unrelated to selective serotonin reuptake inhibitors, tricyclics or monoamine oxidase inhibitors (MAOI). Mirtazapine belongs to the
piperazino-azepine group of compounds.The mechanism of action of REMERON® (mirtazapine) Tablets, as with other antidepressants, is unknown.
Evidence gathered in preclinical studies suggests that mirtazapine enhances central noradrenergic and serotonergic activity. These studies
have shown that mirtazapine acts as an antagonist at central presynaptic a2 adrenergic inhibitory autoreceptors and heteroreceptors, an
action that is postulated to result in an increase in central noradrenergic and serotonergic activity.Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine has no significant affinity for the 5-HT1A and 5-HT1B
receptors. Mirtazapine is a potent antagonist of histamine (Hi) receptors, a property that may explain its prominent sedative effects.Mirtazapine is a moderate peripheral a1 adrenergic antagonist, a property that may explain the occasional orthostatic hypotension
reported in association with its use.Mirtazapine is a moderate antagonist at muscarinic receptors, a property that may explain the relatively low incidence of anticholinergic
side effects associated with its use.It is designated 1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a] pyrido [2,3-c] benzazepine
and has the empirical formula of C17H19N3. Its molecular weight is 265.36.
poster:allisonm
thread:30915
URL: http://www.dr-bob.org/babble/20000420/msgs/31080.html