Re: ? for JohnL serzone dosing

Posted by JohnL on May 18, 2000, at 2:55:45

In reply to ? for JohnL serzone dosing, posted by dove on May 17, 2000, at 8:54:11

> Could anyone explain explicitly why Serzone (nefazodone) is b.i.d (twice daily)dosing? My p-doc has me taking 400mgs in dosages of 100mgs four times a day. What is the significance of this? I miss doses because I'm busy with my five kids, and would really enjoy being free of that med schedule if possible.
>
> Any thoughts are welcome and appreciated :-)
>
> dove
Dove,
Maybe the doctor has a couple things in mind. Serzone's halflife is very short. Maybe that's a consideration. Or maybe he's trying to smooth out any side effects. Clinical trials have shown interestingly that q.i.d. dosing vs b.i.d. dosing showed no difference in therapeutic response. So I don't think multiple dosing has much to do with response, but probably more to do with managing side effects. Just a guess. Next time you see the doc, ask him. I would be interested to know.
JohnL

Thread

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Re: Serzone JohnL 5/17/00
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