Posted by JohnL on May 25, 2000, at 3:17:32
In reply to My Mirapex Trial, posted by AndrewB on May 19, 2000, at 12:49:39
> I have just finished a two week trial with the D2/D3 agonist Mirapex, the last week of the trial I did not take any other medications besides reboxetine. As an antidepressant and anxiolytic, Mirapex seemed to have little or no effectiveness for me. Taking only the Mirapex, I became quite depressed and socially anxious. My energy was good, but this was probably maintained by the reboxetine. For my condition at least, Mirapex appears to be very much inferior to the D2/D3 presynaptic antagonist amisulpride. I have dysthymia with social anxiety. It is possible that this trial was too short to give Mirapex a chance to work, though it is normally effective within a week. Also it is possible that my dosage was too small. I was taking what limited studies indicate is the normal amount.
Hi Andrew,
Thanks for the update. Sorry Mirapex didn't pan out. As you know, I am in the camp that believes 2 weeks was plenty long enough for a fair trial. I mean, sure, perhaps it could have worked better in time through a trickle down process. But I don't think that's what you or I are interested in. We want something that nails it directly, don't we? The fact that you became depressed and anxious is a pretty strong clue, in my opinion at least, that this drug was off-base. I would bet a higher dose and/or more time would not have been a good experience. Though it looked good on paper and in theory, it was a completely different story at a molecular level in your own unique chemistry. But hey, another clue for the puzzle. We never know till we try, right?I just hope you're feeling a little better now. I know how rough it is coming back from the adverse state of mind that a wrong drug creates. No fun. It makes for some very tough long days in survival mode.
So what's next? Any plans or ideas? Any possible thoughts on optimizing Amisulpride?
JohnL
poster:JohnL
thread:34012
URL: http://www.dr-bob.org/babble/20000517/msgs/34567.html