Posted by AndrewB on May 25, 2000, at 8:28:50
In reply to Re: Dr. Goldstein'sWeb...AndrewB, posted by JohnL on May 25, 2000, at 4:29:37
I haven't looked all that deeply into Dr. Goldsteins's background. But there are a few things that make me think he may be legit. For one, a couple of other doctors who are CFIDs specialists quote his work and one refers to him as an important and innovative figure in the field. Beyond this, his methods have received grant funding in order that they can be evaluated for their efficacy. So maybe he is legit.
Dr. Goldstein uses short acting drugs (or drugs in short acting forms) as diagnostics tools to determine dysfunction in targeted receptor systems. For example, amantadine is used as a diagnostic to determine if there is dysfunction in the ketamine or dopamine receptor systems.
Anthony, based on my own experience, I don't have too much trouble believing that neurontin or some other seemingly unlikely drug would make someone with CFS feel suddenly better. Myself, I have basically a hybrid disorder that is in part dysthymia and in part CFS. Heavy exercise brings on quite rapidly in me depression, irritability, muscle and joint pain, fatigue, muddled thinking and (social) anxiety). All these symptoms, except for the muscle and joint pain, are able to be ameliorated in the better part quite rapidly by the D2-D3 dopiminergic agent amisulpride. And indeed, research has shown that fatigue and social phobia are associated with hypofunction of the D2 receptors, and low mood can be caused by D2/D3.
Another drug out there was, like magic, able to take completely all my dysthymia/CFS symptoms. It was the street drug GHB. I bought it over the internet when I read that even though this drug was used to induce a heavy sleep (or in lower doses a drunken feeling), there would be an atypical reaction to GHB if you were a depressive. Instead of making you sleepy, the interent site said, you would feel energized and your depression would disappear. And indeed it did. Believe me, I'm not recommending GHB, it has withdrawal symptoms, induces mania, and has an inappropriatly short half life. My point is, however, that a particular atypical reaction may be expected to occur if there is a certain underlying receptor dysfunction. This seems to be what is occurring with that patient's atypical reaction to neurontin.
I have located a copy of Goldstein's book in the local library system and I am eager to take a closer look at what he has to say and hopefully come away with a greater understanding of the causes and the potential agents of relief for CFS and fibromyalgia.
poster:AndrewB
thread:34515
URL: http://www.dr-bob.org/babble/20000517/msgs/34587.html