Posted by michael on May 30, 2000, at 14:00:15
In reply to Re: Amisulpride and Selegiline, posted by AndrewB on May 30, 2000, at 1:57:39
> > How about selegiline 10mg/day and low dose amisulpride?
> >
> > I think both work to increase dopamine levels, although via different mechanisms?
> >
> > Theoretically, would therefore potentiate/reinforce each other?
> >
> > Any thoughts - or corrections, etc?
>
> Michael,
>
> I've thought about combining selegiline and amisulpride. They could potentiate one another. I remember someone saying that they had combined selegiline (low dose) with amineptine, another dopaminergic. It seems though from the posts I've read and other personal reports that selegiline has little or no noticeable psychological effect on people at low doses. With this is mind, I wonder just how effective a potentiator of amisulpride it might be. I am going to try entacapone, a COMT inhibitor that acts to increase dopamine at the synapse, as an augumentator to amisulpride. Hydergine, a smart drug, is also dopaminergic and another possible augmenting agent for those with mental slowness.
>
> Michael, what have you decided on the adrafinil. Is it working for you? I might try it as my reboxetine pooped out.Andrew -
I know that selegiline isn't thought to be an effective AD at those low doses. But if I understand correctly, 10mg selegiline/day is sufficient to inhibit all MAOI-B in the brain (read it on the clinical pharmacolog 2000 site), which is the one which works primarily on Dopamine. I was thinking that therefore, it might potentiate the amisulpride...
As for the adrafinil - I had a week or two when I didn't take anything. I then started taking the adrafinil, and noticed a subtle but significant effect - more energy, less social withdrawl... Didn't "feel" stimulated, just normal for a change - not constantly run-down, tired, etc.
This was the case for about a week. At that point I got sick - the cold from hell. The first week, I was miserable, the second, I started to feel human again. But while I was sick the adrafinil couldn't break through the misery.
About this time, I also re-started wellbutrin SR, at 400mg/day, to try and quit smoking - completely.
Anyway, still taking the adrafinil. It helps somewhat - not to the degree it did that first week. (I tried skipping it, and it does still help) I'm wondering if it might be more effective again by itself, when I stop the wellbutrin (which unfortunately won't be for a while), or if it just "pooped-out", or if it's just an issue of building tolerance. (tolerance isn't supposed to be as much of a problem w/adrafinil as it is w/other stim's, since it's so focused on alpha-1 receptors - I believe)
I'm going to expirement with increasing the dose, to try to determine if it is a tolerance issue (ie: if I need increasing doses to get the same effect it had initially), or if maybe the wellbutrin makes a higher dose necessary...? or if it's just "pooped-out"...
I've been away for a while - what has been JohnL's experience - is it still working? JohnL...?
I'm also experimenting w/LOW dose amisulpride, as you suggested, since the 50mg/day made me sleep sooo much (like you mentioned, that seems to be a side effect more associated w/higher doses/overdose - if I've read the research correctly...?) So 1/4 of a tablet/day (approximately 12.5 mg/day). I did it for about a week, and the most noticeable effect was increased libido, and elimination of problems with erection which the adrafinil had induced.
I'm planning on trying it again for another week, to see if I get the same results, and pay more attention for any other, more subtle results.
And as I mentioned initially, I'm also interested in experimenting a bit w/low dose selegiline, both in place of, as well as in in addition to the amisulpride.
I'm trying to just change one variable at a time - difficult to be patient enough, now that I finally have some ideas that I want to try... Oh yeah, I also have some reboxetine, but haven't had the time to give it a try yet, w/all the other "trials" I'm trying.
Hope that ramble is coherent/makes sense... As always, I'd be interested in any comments/insights, suggestions, etc. that anyone may have... michael
poster:michael
thread:34862
URL: http://www.dr-bob.org/babble/20000526/msgs/35248.html