Posted by Tina1 on June 9, 2000, at 14:58:36
In reply to Re: MAOI Reaction Symptoms -SCOTT, posted by SLS on June 9, 2000, at 13:22:28
Quite a list of questions. Here goes:
I was taking it for depression/anxiety
I discontinued it because I felt that I was cured and i think I was a little cockey
I titrated up to 450mg/day slowly and stayed there with no increases over the two year period
I take clonazepam 1.5-2mg daily to control anxiety/panic attacks.
Thanks for being interested, I love this place. You are a very knowledgable person and have found your posts insightful and informative. You're a great asset to this board.
Love ya
Tina> > Scott---I was on Manerix 7 years ago and stayed on it for 2.5 years. I never had one single problem and I didn't even know that I was supposed to change my diet. I eat cheese by the brick, pepperoni pizzas, processed lunchmeat etc. Is it possible that I'm just not sensitive to this syndrome? Oh, BTW, I'm taking Manerix again now. Been on it 3 days. Take care--Tina
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> Hi Tina,
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> I'm glad you posted a reply.
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> I did not do a good job of describing Manerix. I should have stated that the risk of experiencing a hypertensive reaction to tyramine is reduced for Manerix (moclobemide). It is also reduced for Eldepryl (selegiline, deprenyl) when it is taken at dosages of 30mg or less. I tried to emphasize the fact that neither of these two drugs are free of the potential to cause it. The potential is not simply theoretical, it is documented. However, the incidence of this happening is infrequent. The term "wide safety margin" has been used.
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> One of the putative advantages of using Manerix is that there is no need to adhere to a special diet. I really don't know on what side of the fence to stand on this issue. When I tried it a few years ago, I remained cautious about my choices of foods. I was not willing to tempt fate by eating a chunk of cheddar or blue cheese and washing it down with a bottle of chiante. I have seen recommendations that when Manerix is taken at dosages of 600mg and higher, the tyramine content of a meal should not exceed 50mg.
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> I think the words you used were well chosen. You are not sensitive to this syndrome.
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> Thanks for helping to create a more balanced view regarding Manerix and the low-tyramine diet. A good Canadian pharmacist would be able to offer some valuable input based upon his experience with it. Just in case, I'll offer the Good Lord a little prayer for you. *** Now you're immune. :-)
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> For what ailment are you taking Manerix?
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> Why did you discontinue Manerix?
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> What dosages do you use?
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> Did you find that you needed raise the dosage a few times when you began taking it the last time?
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> Are you taking any other drugs along with it?
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> Thanks.
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> GOOD LUCK!
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> - Scott
poster:Tina1
thread:35949
URL: http://www.dr-bob.org/babble/20000603/msgs/36735.html