Posted by SLS on June 13, 2000, at 7:44:11
In reply to Re: Scott, posted by AndrewB on June 12, 2000, at 15:55:51
> Scott,
>
> I haven't found entacapone to be very useful by itself. That shouldn't be surprising as it only generates a 30% COMT inhibition. Soon I will combine it with Sinemet (l-dopa +) to see what happens, and after that probably throw selegiline into the mix. There are couple other combo.s I might also try. If one of the combo.s is effective, I will then try to figure out if it is safe to use long term. Anyway I will of course let you know how it goes.
>
> I am currently giving naphazoline a trial (See the above post entitled 'For those interested in reboxetine or adrafinil'). Naphazoline seems to me to be a perfect diagnostic tool to determine if a person would respond to some NE active drug such as adrafinil. Imagine if one of the first things a psychiatrist did with a patient was to administer naphazoline eye drops! I'm trying now to see if I want to keep using naph. over the long term.
>
> I also tried Mirapex at 5mg./day, as the latest study indicated this was the most effective dose. I had already once before given it a trial at a much smaller dose. It was a failure. This time at 5mg. Mirapex still didn't substitute (at all!) for amisulpride. I think I took the Mirapex for four days at 5mgs. before I stopped the amisulpride. Two days later, CRASH! The depression and anxiety came rushing back. So I quickly restarted the amisulpride. So what do you think. Why doesn't Mirapex help me at all?
>
> AndrewB
If I could answer questions like that I wouldn't be answering questions like that.I guess one pathetically simplistic explanation would be that there is a perturbation in the balance of presynaptic versus postsynaptic DA receptor sensitivities, with presynaptic being heavily favored. This would account for the reason why amisulpride might be so effective, and possibly why you are vulnerable to a depressive rebound upon its withdrawal. In this scenario, it is even possible that low dosages of Mirapex would make you feel worse.
By the way, how have you responded to MAO inhibitors?
I REALLY appreciate your willingness to post your reactions to the different treatments you have been trying. There is probably a greater diversity of pharmacological approaches to treatment here than at any single research institution in the world. As much as I am personally profiting from the information your experimentation with different drugs provides me, I remain concerned that you not do anything that is not in your own best interests. Please be careful.
Sincerely and Gratefully,
Scott
poster:SLS
thread:36914
URL: http://www.dr-bob.org/babble/20000610/msgs/37132.html