Posted by Ant-Rock on June 15, 2000, at 8:28:28
In reply to Re: Parnate and Adrafanil?, posted by JohnL on June 15, 2000, at 3:39:12
> Anthony,
> I don't know anything about Nivalin.
>
> But I am familiar with Adrafinil and I don't see any reason you couldn't combine it with Parnate. My primary concern would be the combined effect of hyperadrenergic effects, which would likely manifest itself in feelings of agitation or irritation or worsened depression.
>
> Since neither Ritalin or Amisulpride are cutting it, that kind of hints that dopamine is not a chemistry you respond to. So that makes the case for Adrafinil more convincing, since it acts on the NE system rather than the dopamine system. Also worth considering is that neurotransmitter levels with you could likely be OK, and down-regulation by increasing those levels not necessary. If your levels were low, or down regulation needed, then I would think you would have had a more positive reaction to Parnate alone. It's just a guess, and you know better than me, but the whole Parnate thing might be off target.
>
> Personally I found Adrafinil to be the kindest gentlest and yet most effective of all the stimulants. But that's just me.
>
> In your shoes I would start by cutting a 300mg pill into halves and start with 150mg a day for a week just to feel it out and test the waters before jumping in. But again, that's just me. I tend to be cautious, and I believe in low and slow, especially when dealing with medications our personal physicians are not real familiar with. If after a week all is well, then higher doses could be tried.
>
> In one source I noticed Adrafinil's usual dose is 600mg to 1200mg. In another it is 300mg to 600mg. Personally I found 300mg perfect, after trying all different doses.
> JohnLThanks for the response John,
Parnate is helping in some ways, just not completely. Anhedonia and apathy still strongly pervail. This is what led me to believe Dopamine must be responsible. The funny thing about Ritalin is that at first I began getting a positive response at a low dose, but it was short lived and never returned with either gradual increases, or augmenting with parnate.
I find what you said about neurotransmitter levels being ok very interesting, i just don't know enough about this stuff to really grasp this theory.
Anyway, I actually started with 1/2 adrafanil pill yesterday, and just took my second dose today and will stay at this 1/2 dose for a week like you suggested.
Again John, thank you so much for your response, I was afraid I wasn't gonna get a reply.
Sincerely,
Anthony
poster:Ant-Rock
thread:37287
URL: http://www.dr-bob.org/babble/20000610/msgs/37364.html