Posted by SLS on June 24, 2000, at 15:36:47
In reply to Re: adrafinil, posted by michael on June 21, 2000, at 13:17:52
> It, like provigil, is thought to work via stimulation of the alpha-1 receptors - which are the receptors norepinephrine stimulates.
>
> However, they're not exactly sure of the precise mechanism or method of action for either (I believe all of the above is accurate - someon please correct me if I'm mistaken, or add if I've left stuff out)
I get the impression that the increased levels of extracellular glutamate produced by Provigil may play a greater role in its effects on mood and wakefulness than does alpha-1 agonism. Most of the newer stuff I see on Medline indicates that alpha-1 receptor pathways must be intact to facilitate the effects of Provigil, but are not necessarily affected directly by it.I'd like to see the original studies that determined the "putative" binding of Provigil to NE alpha-1 receptors. Can anyone provide references? From what I can see, it may not do so at all. The package insert declines to include it as a possible mechanism of action.
I doubt Provigil is an alpha-1 agonist as it does not prevent or mitigate cateplexy in narcolepsy.
- Scott
poster:SLS
thread:37844
URL: http://www.dr-bob.org/babble/20000619/msgs/38275.html