Posted by Cam W. on July 3, 2000, at 13:25:25
In reply to Thanks Cam, posted by Leong Khah Loon on July 3, 2000, at 11:04:38
> Thanks Cam
>
> i think thats what my prof want
> if for experiment purpose
> that mean a DRUGS (named X )add in sugar
> (eg. fructose or maltose) then go through a process then become a salt (or tablet form and inactive form).
> so
> X + sugar --- process ---> Xxx(salt) + H20
> Sir, i need more information on the sugar n process
>
> IS that all the drug will react with fructose or maltose ? I heard danf said that not all the drugs react.
>
> and for the process is that we mix the sugar n drugs and add in some water then Vacumn it to separate the H2O then to get the salt or mix them and heat it up or other process ?
>
> hope Sir can give me more information.
> Thanks Again
> LoonLoon - What you are talking about is 2 separate processes.
1) Transforming a drug in solution to a solid powder.
- commonly hydrochloric acid (HCl) is added to a drug solution whose pH is above 7 (below pH of 7 - a basic solution is used - will have a -OH group in the molecule). The HCl in solution dissociates to hydrogen ion and a chloride ion. The chloride ion binds to the drug in solution and causes the drug to precipitate out. The hydrogen ion from the HCl and the hydroxyl group from the the drug solution turns into water. This water is vacuumed off or is left to evaporate.2) Turning powdered drug into a tablet.
- This is where the sugar, binders and other excipients (fillers) are added to the drug and pressed into a tablet. Most of the ingredients will be dry, so there is no need to remove water.Hope this is clearer - Cam
P.S. danf is right about the characteristics of the fillers.
poster:Cam W.
thread:38732
URL: http://www.dr-bob.org/babble/20000630/msgs/39167.html