Posted by SLS on July 7, 2000, at 11:45:08
In reply to Re: Cam - Zofran?, posted by Cam W. on July 6, 2000, at 14:44:07
> Greg - I believe that Zofran is a selective serotonin-3 (5HT-3) antagonist. 5HT-3 receptors are mainly found in the small intestine (and in the CNS to a lesser degree). By blocking this receptor you decrease the nausea. The 5HT-3 receptor is responsible for the nausea seen as a start-up side effect of the SSRIs. Stimulation of the 5HT-3 receptor by the increased serotonin (as a result of the SSRI) causes nausea, which is resolved when this receptor is desensitized (usually within the first month after starting the SSRI). They use Zofran a lot after chemotherapy.
What is the generic name for Zofran?Where does Zofran exert its antiemetic effects - brain or gut?
Is Zofran devoid or 5-HT2 antagonism?
- Scott
poster:SLS
thread:39559
URL: http://www.dr-bob.org/babble/20000630/msgs/39677.html