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Dopamine agonists for patients who lose response t

Posted by stjames on July 8, 2000, at 0:21:47

This is from Dr Bob's tips and tricks section at
http://www.dr-bob.org/tips/


Date: Mon, 3 Apr 1995 05:29:28 -0700 (PDT)
From: Ivan Goldberg
Subject: Dopamine agonists for patients who lose response to an SSRI

It has been hypothesized by Don Klein and others that what looks like decreased antidepressant effectiveness is really a state of akinesia resulting from depletion of dopamine with continuing use of the SSRIs. Based on this understanding one can treat the apparent fall-off in SSRI effectiveness with DA agonists such as bupropion, amantadine, methylphenidate, dextroamphetamine, etc. I have done this on many occasions, often with excellent results.

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