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MAO-B inhibitor + dopamine-releaser dangerous?!

Posted by S.D. on July 17, 2000, at 1:39:54

I'm concerned about some people here who may be combining an MAOI with a stimulant or adrafinil or amisulpride, so if that's you, please let me/us know how you are doing.

The selfish part of my concern is that I'm taking the OTC "herbal supplement" kava (for social anxiety) which is a reversible inhibitor of MAO-B. (MAO-B is the one that oxidizes dopamine and PEA).

I don't want to stop the kava if it is unlikely to be a real danger, although I know it's also possible either could inhibit the effectiveness of the other. Since I can't find any direct indication at all that this particular combination is unsafe, the only thing I wonder is if a sufficient degree of MAO-B inhibition would cause a problem with the dopaminergic effect of low-dose amisulpride.

So please let me know if you have any specific idea that I'm "heading for trouble"!

Thanks, peace and health,

S.D.


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poster:S.D. thread:40697
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