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Re: Manerix augmentation with Lithium--Thanks Cam

Posted by tina on July 20, 2000, at 11:43:07

In reply to Re: Manerix augmentation with Lithium » tina, posted by Cam W. on July 20, 2000, at 0:16:49

You wealth of info you! I just love ya. Thanks a million Cam.
I hope you are having a glorious day!
Tina


> Tina - Lithium is often used to augment antidepressants. Figuring out the dose you would use with an SSRI is a little harder than with the Manerix. Serotonin syndrome (too much serotonin) has happened with the SSRIs, but I haven't heard of it happening with Manerix.
>
> Lithium itself has antidepressant properties, as well as anti-manic activity. The principle behind this combination is most likely an additive effect of the 2 antidepressants. The Manerix stops the metabolism of neurotransmitters (serotonin, etc) implicated in depression (thus increasing the neurotransmitter concentrations). The lithium probably stabilizes the calcium ion concentrations inside nerve cells resulting in a more efficient nerve cell that can transmit an electrical signal more effectively.
>
> The above is a guess, but I think it may make some sense. I do not think anyone is really sure why lithium augments antidepressants, it just does.
>
> Hope this helps - Cam


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