Posted by tina on July 20, 2000, at 11:43:07
In reply to Re: Manerix augmentation with Lithium » tina, posted by Cam W. on July 20, 2000, at 0:16:49
You wealth of info you! I just love ya. Thanks a million Cam.
I hope you are having a glorious day!
Tina
> Tina - Lithium is often used to augment antidepressants. Figuring out the dose you would use with an SSRI is a little harder than with the Manerix. Serotonin syndrome (too much serotonin) has happened with the SSRIs, but I haven't heard of it happening with Manerix.
>
> Lithium itself has antidepressant properties, as well as anti-manic activity. The principle behind this combination is most likely an additive effect of the 2 antidepressants. The Manerix stops the metabolism of neurotransmitters (serotonin, etc) implicated in depression (thus increasing the neurotransmitter concentrations). The lithium probably stabilizes the calcium ion concentrations inside nerve cells resulting in a more efficient nerve cell that can transmit an electrical signal more effectively.
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> The above is a guess, but I think it may make some sense. I do not think anyone is really sure why lithium augments antidepressants, it just does.
>
> Hope this helps - Cam
poster:tina
thread:40976
URL: http://www.dr-bob.org/babble/20000717/msgs/41037.html