Posted by SLS on August 6, 2000, at 8:00:00
In reply to Scott, posted by AndrewB on August 5, 2000, at 22:06:01
Hi Andrew.
> I don't know how adrafinil works, but these short term effects with adrafinil aren't alpha1 andrenergic agonism, based on my experience with rebox. and Naphazoline.
What did you experience when you introduced naphazoline? Are there any NE alpha-1 agonists available that cross the blood-brain barrier?
> I suspect glutaminergic. This concerns me because excess glutamate is known to be neurotoxic as well as excitatory.
I didn't know that. One of the abstracts I came across on Medline hinted that Provigil may exert some neuroprotective effects on striatal dopaminergic neurons and glial cells. Sometimes, I think such conclusions are impelled by wishful thinking. I don't know. Upon which cells is excess glutamate known to be toxic?
> I am trying adrafinil for the 1st time. Rebox. started to poop out on me.
That sucks.
> Nice to be free of the sexual side effects of rebox. Rebox. also limited my athletic stamina severely.
From this, I surmise that you have discontinued reboxetine. I would just point out that you used the phrase "started to poop out". If you retain some positive effect from reboxetine, you may want to consider returning to it as an adjunct if necessary. I'm guessing that you would not have discontinued it if it were not for the unwanted side effects it produces. I know how quickly I want to discontinue a drug that is not producing satisfactory results if it means I can escape its side effects.
> Will try ritalin and adderall next as a trial.
This was my first thought even before I had read this far. However, the thought was to add it as an adjunct to reboxetine. Of course, there have been descriptions on Psycho-Babble of people who find Adderal to be a necessary adjunct to adrafinil to produce a robust improvement. I would make Adderal my first choice.
> I don't need that much arousal. I'm not that bad off now. Some daytime sleepiness, you know, but not really fatigue. Maybe the selegiline I'm taking has helped me out a bit in respect to arousal.
Did reboxetine lose its effect after you added selegiline or before?
> I have concluded that selegiline solidiifes the action of amiuslpride for me, making me not wilt under stress.
This is why I had thought to add sulpiride/amisulpride to Parnate.
> Also I have less social anxiety, I have an acceptable amount now. No side effects for me on selegiline.
May the force be with you...
On a personal note: After the first few days of taking Neurontin, I have begun to see diminishing returns. More importantly, I have experienced the induction of significant cognitive disturbances. This has occurred at a dosage of 900mg. My experiences in the past indicate that this is probably less dosage dependant and more time dependant. My motivation to take Neurontin Tuesday night was to reduce the great anxiety and depression that I was sure would prevent me from driving to my doctor's office for my appointment the next morning. When I found that the anxiety and depression had abated significantly, I decided to continue with it. However, it really wacked me out yesterday evening after taking a 200mg dose that represented a total of 800mg for the day. I have now decided to discontinue it by decreasing the dosage slowly. I am afraid of this drug.
- Scott
poster:SLS
thread:42223
URL: http://www.dr-bob.org/babble/20000729/msgs/42283.html