Posted by AndrewB on August 18, 2000, at 18:30:50
In reply to Re: adrafinil,sulpiride/amisulpride,update Jensen » JohnL, posted by michael on August 18, 2000, at 17:18:38
Michael,
Amisulpride, up to 200mgs. is a presynaptic D2/D3 receptor antogonist. At higher doses, a postsynaptic receptor antogonist.
Sulpiride has a similar low dose/high dose D2/D3 receptor antagonism dichotomy.
Bromocriptine is (if I remember right) a D2 receptor agonist.
I read of a report where a women was taking sulpiride but had side effects due to raised prolactin levels (i.e. missed menses). Upon adding bromocriptine, the side effects disappeared while response to sulpiride was maintained.
I asked my psych. about the combo. of bromocriptine and amisulpride. He did not express a problem with it.
I have taken the D2/D3 agonist Mirapex (pramipexole) concurrently with amisulpride. The Mirapex did not diminish the effect of the amisulpride or cause any side effects.
JohnL, note that the adding of bromocriptine to amisulpride/adrafinil combo may well remove the sexual side effects you experience with this combo. Bromo. lowers the prolactin levels that amisulpride can raise. Raised prolactin levels can cause sexual dysfunction. Also note a posting above that where bromo. counteracted sexual dysfunction from adrafinil.
Also JohnL, I recently trialed Provigil and Adrafinil. Extreme headaches with both. Couldn’t stop the headaches with common headache meds or a beta blocker. Remember Scott saying he had heard that adrafinil was not (at least directly) (alpha 1) noradrenergic in action. I’m wondering if adrafinil’s action is, in the main, glutaminergic. Remember that provigil is a metabolite of adrafinil, so one would presume they have overlapping modes of action.
Best wishes,
AndrewB
poster:AndrewB
thread:42846
URL: http://www.dr-bob.org/babble/20000811/msgs/43264.html