Posted by Peter S on September 8, 2000, at 0:40:58
In reply to Re: SAM-E appears to be working, posted by AndrewB on September 7, 2000, at 21:45:14
Andrew,
Thanks for the idea; I will definitely keep it in mind if this regimen doesn't work out. Where and how do you get Mirapex?
Peter
> Peter,
>
> I hope that SAMe is the thing that you needed. Keep us posted.
>
> I am doing really, really well; good mood, confident, good energy and motivation. I hope this is here to stay.
>
> When compiling the amisulpride mini-survey I was reminded that you were one of the ones who didn't respond to amisulpride. Were you taking Nardil at the time? I thought that you had the perfect profile for someone that would respond; dysthymic, having social anxiety, and having responded to Nardil (whose effectiveness is in part due to dopaminergic action).
>
> An idea keeps going through my head that some people may not respond to amisulpride yet still have D2/D3 receptor dysfunction. Maybe somehow the amisulpride doesn't work for them because it isn't able for some reason to antagonize the pre-synaptic receptors.
>
> However, even when amisulpride fails to work, maybe another drug that works on the D2/D3 receptors may work.
>
> I thinking of the drug Mirapex (pramipexole). It, like amisulpride, acts on the D2/D3 receptors, but it works by a very different mode of action; it is a post-synaptic agonist not a pre-synaptic antagonist like amisulpride.
>
> The one major study done with Mirapex showed it to be quite effective for depression. When I took it I found the side effect to be mild and transient.
>
> If you want to consider taking Mirapex, I'll be glad to send you more information on it.
>
> AndrewB
poster:Peter S
thread:44433
URL: http://www.dr-bob.org/babble/20000905/msgs/44463.html