Posted by anita on September 12, 2000, at 0:28:34
In reply to MAOI personality change?, posted by Veronica on September 9, 2000, at 16:39:28
Hi,
Increases in noradrenaline and dopamine (which occur with MAOIs) can result in irritablity or agression. Every noradrenergic or dopaminergic med I've tried eventually made me very irritable. Three possible ways to go: add on a mood stabilizer like lithium; add high dose propananol; add a low dose of zyprexa or risperidone (atypical antipsychotics). These have all been proven to reduce irritability and agression, and would also help if the MAOI has switched him into a hypomanic mixed state.
good luck,
anita
> My husband has been treated for major depression & anxiety for several years. In February of this year, we finally got his pdoc to try something different...a MAOI, Nardil. Nothing he had tried previously had provided any real relief. Anyway, the Nardil seems to have conquered the depression for the most part. Anxiety isn't really an issue at this time either. The problem is that my husband has had a major negative personality change. His whole appearance has changed. He snaps at me without reason. It's gotten so bad that he says he's not going to my sister's wedding next month & now she doesn't even want him there because he's been treating her bad too.
>
> My question is if this change is in any way possibily related to Nardil, and if so what to do about it. I am not willing to continue in this situation much longer at the rate it's going. I have been a supportive wife for 7 years, but I just don't deserve this current treatment.
>
> Thanks for your comments.
poster:anita
thread:44526
URL: http://www.dr-bob.org/babble/20000905/msgs/44653.html