Posted by AndrewB on October 20, 2000, at 17:25:27
In reply to Selegeline Patch - Update?, posted by Deborah14 on October 19, 2000, at 21:09:36
Deborah,
This isn't a topic I'm up on but if you do a search of past posts you will find that Adam posted a lot of info. about the patch. As I remember, he found the patch much more effective than the oral selegiline and a lower dose was required to be effective, no dietary restrictions, and there was less of a problem with jitteriness and insomnia. He said some months back was that the patch was unavailable at that point.
You might want to see if a compounding pharmacist can make up a patch or some other transdermal delivery system for selegiline. Try calling Liberty Drug about this, 1-800-58-LIBERTY.
The sleeplessness is caused by selegiline metabolizing into amphetamine and metamphetamine. This suggests that you may find an effective alternate treatment, without the side effects, with the combination of low dose selegiline (5-10mg/day, so only MAO-B inhibition is taking place) along with amphetamine taken during the day (i.e. adderall) and, if necessary, a reversible MAO-A inhibitor (i.e. moclobemide, reportedly few side effects, see Dr. Bob's tips section).
AndrewB
poster:AndrewB
thread:46818
URL: http://www.dr-bob.org/babble/20001012/msgs/46900.html