Posted by SLS on November 8, 2000, at 22:27:44
In reply to Re:More on Viloxazine. Betamimetic AD? Scott, posted by Anna P. on November 8, 2000, at 21:40:50
Dear Anna,
betamimetic = mimic beta stimulation
What I think they mean is that viloxazine somehow selectively stimulates NE beta receptors and not the other noradrenergic receptors. When stimulated, these NE beta receptors act to increase heart-rate and blood pressure. This is why beta blockers like Inderal are useful in treating hypertension and controlling heart-rate.
I don't know enough about viloxazine to know whether its betamimetic properties are produced by a mechanism other than NE reuptake inhibition. If it does, reboxetine + viloxazine would produce an increase in heart-rate greater than reboxetine + tricyclic.
I hope this explanation is helpful.
- Scott
> > Hi again.
>
> I found more info on Viloxazine. I'm concerned, and I dropped Reboxetine from my combo today after having heavily increased heart rate.
> According to my research , I know that Viloxazine is contradicted with Carbamazepine, as it increases its blood level.
> How about Neurontin?
> I need to take Neurontin as it makes ADs to work to some extent.
> Viloxazine works with Neurontin for now.
> But I've found out that a drug has the anticonvulsant and proconvulsant properties.
>
> 1.Psychopharmacology (Berl) 1982;76(3):212-7
> Anticonvulsant and proconvulsant properties of Viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon.
>
> 2.Neuropsychobiology 1987:17(1-2):35-40
> Viloxazine as a betamimetic antidepressant drug
>
> A comparison was made between the effects of maprotiline, the sole action of which is to inhibit the reuptake of noradrenaline, of salbutamol and of viloxazine on hypothermia induced by reserpine, oxotremorine or apomorphine. The dose/effect curves in the three tests showed a similarity in profile between viloxazine and salbutamol, whereas no resemblance was evident between these two drugs and maprotiline. These facts suggest that viloxazine which has a weak effect on noradrenaline reuptake acts probably as antidepressant by betamimetic activity.
>
> Scott, what does betamimetic activity means?
>
> Anna P.
poster:SLS
thread:48258
URL: http://www.dr-bob.org/babble/20001102/msgs/48488.html