Posted by SLS on November 28, 2000, at 21:31:26
In reply to Does Imipramine do more for noradr. or serotonin?, posted by PhoenixGirl on November 28, 2000, at 11:53:13
> Does anyone know which chemical imipramine has a greater effect on -- noradrenaline or serotonin?
Hi PhoenixGirl.= > Arise from the ashes?
Most of the tricyclic antidepressants are more potent reuptake inhibitors of norepinephrine (noradranaline) than they are of serotonin. Imipramine falls into this category. Clomipramine (Anafranil), and possibly amitriptyline (Elavil), display some potency of the reuptake inhibition of serotonin. In fact, clomipramine produces some side effects known to be common with the SSRIs (selective serotonin reuptake inhibitors), including anorgasmia.Imipramine is metabolized by the body into desipramine. During therapy, the blood levels of desipramine are far higher than those of the parent compound, imipramine. Desipramine is the most selective reuptake inhibitor of norepinephrine among the tricyclics. It is similar to reboxetine in this regard.
- Scott
poster:SLS
thread:49556
URL: http://www.dr-bob.org/babble/20001115/msgs/49579.html