Posted by JohnL on December 2, 2000, at 5:56:12
I don't quite follow this technical stuff. But this research abstract tends to imply to me that somehow the alpha-1 and dopamine D2 chemistries are interrelated.
Perhaps somewhere in this complicated chemistry it might be explained why Adrafinil + Amisulpride works well for me? Adrafinil=alpha1, Amisulpride=D2.
Any comments or explanations from the technical experts out there?
Thanks,
John
1: Psychopharmacology (Berl) 1990;101(1):62-6
Related Articles, Books
Effects of single and repeated treatment with
antidepressants on apomorphine-induced yawning in
the rat: the implication of alpha-1 adrenergic
mechanisms in the D-2 receptor function.Delini-Stula A, Hunn C
Research Laboratories, CIBA-GEIGY Ltd., Basle, Switzerland.
Acute (10 or 20 mg/kg IP) and subchronic (2 x 5 or 10 mg/kg IP daily for
7 days) effects of desipramine, imipramine, maprotiline, (+)- and
(-)-oxaprotiline enantiomers as well as selective 5-HT-uptake inhibitors
citalopram and ifoxetine on yawning, induced by low doses of
apomorphine, were investigated in the rat. In addition, the effects of
alpha-1 receptor agonist adrafinil and antagonist prazosin were also
tested. After acute treatment, desipramine, the stereoselective NA-uptake
inhibiting (+)-enantiomer of oxaprotiline, and the alpha-1 agonist adrafinil,
markedly and significantly suppressed yawning. Prazosin, in contrast,
clearly potentiated it. This potentiating effect was abolished by the
pretreatment with (+)-oxaprotiline and adrafinil. Other drugs were
inactive. After subchronic administration, yawning was antagonized by
NA-uptake-inhibiting antidepressants, including imipramine and
maprotiline. By comparison to the acute treatment, the inhibitory effects
of desipramine and (+)-oxaprotiline were considerably enhanced. Neither
selective 5-HT-uptake inhibitors nor (-)-oxaprotiline (levoprotiline) were
active. Antidepressants therefore modulate the functional activity of D-2
receptors, activated by low doses of apomorphine, predominantly by the
virtue of their noradrenergic enhancing properties. This modulatory effect
appears to be mediated by alpha-1 adrenergic receptors.PMID: 1971448, UI: 90260109
poster:JohnL
thread:49799
URL: http://www.dr-bob.org/babble/20001130/msgs/49799.html