Posted by michael on December 9, 2000, at 12:54:22
In reply to Re: AD and sexual desire stimulation !, posted by natg on December 9, 2000, at 12:22:09
I came across this this morning, and thought I'd post it, for what it's worth... nothing terribly new, but it might contain some useful info for someone... The table format gets lost when I paste it, but I think it's still comprehensible. The format is Antidote/Dosage/Comments/Reported Effects (ie: libido, arousal & orgasm)
Hope it makes sense.
Pharmacologic Antidotes for Antidepressant-Associated Sexual Dysfunction
Antidote Dosage Comments Reported Effects*Stimulants†
Methylphenidate 5-40 mg/d
Dextroamphetamine 5-40 mg/d
Pemoline 18.75-75 mg/d
For SSRIs or venlafaxine
Avoid night dosing (insomnia)
Check liver function
Libido, arousal, orgasm
Ginkgo biloba extract† 180-240 mg/d, tid divided doses Potential increased clotting time, possible flatulence Libido, arousal, orgasm
Cholinergic enhancers†
Bethanechol
Neostigmine
10-50 mg prn
1 hour before sex or 50-200 mg/d, tid divided doses Used for antidepressants with anticholinergic side effect, TCAs, paroxetine
Cholinergic side effects Arousal
Estrogen creams or lubricants As needed For vaginal dryness, atrophy of vaginal tissue Arousal
Amantadine 100 mg bid Caution in patients predisposed to psychosis Orgasm
Cyproheptadine 4-12 mg qhs MAOIs, TCAs, SSRIs, venlafaxine; watch for reemergence of depressive symptoms; sedating Orgasm
Buspirone† 30-60 mg/d, bid divided doses -- Libido, orgasm
Bupropion† 75-150 mg/d, qd or bid divided doses For SSRIs or venlafaxine, fluoxetine may raise bupropion levels; usual precautionary measures for bupropion Libido, arousal, orgasm
Mirtazapine† 15-45 mg/d For SSRIs, venlafaxine Orgasm
Nefazodone† Start 50 mg/d, up to 150 mg/d SSRIs, venlafaxine Orgasm
Granisetron† 1 mg prn ? Use of other 5-HT3 antagonists Orgasm
Sildenafil 50-100 mg/d Contraindicated with nitrates Libido, arousal, orgasm
Yohimbine† 5.4 mg tid Can be anxiogenic; ? safety with MAOIs Libido, arousal, orgasm
5-HT3 = serotonin-3
MAOI = monoamine oxidase inhibitor
SSRI = selective serotonin reuptake inhibitor
TCA = tricyclic antidepressant
* The sexual phases that the antidote is reportedly effective in treatment out of 3 possible phases that may be affected by the antidepressant.
† non-FDA-approved use.> Hi everyone,
> >
> > I'm still trying meds for the moment, and to my great astonishment, my last trial is stimulating sexual desire ! : it's a little quantity of Miansérine (more or less like Remeron), plus lithium, plus Ritalin. I don't think one of these med can create desire on its own, but it's the mixture of the 3.
> > As there is so much sexual dysfunction with AD, I thought it would be useful to share this information.
> > Sigolène.
>
> Hi Sigolene:
> I was wondering how you were doing! Did you just add the Lithium to your regimen? How much are you taking?
> I'm glad you are doing well.
>
> Best of health to you,
>
> Nat
poster:michael
thread:50255
URL: http://www.dr-bob.org/babble/20001130/msgs/50262.html