Posted by Maniz on December 10, 2000, at 17:09:30
In reply to Re: Olmifon : tolerance buildup, posted by J. Lester on December 10, 2000, at 13:40:10
Hi, sorry to mess in your question to JohnL
I am not sure about this info, but it seems inositol resesitizies receptors?
http://home.vicnet.net.au/~mecfs/general/goldstein_treatment.html
46. "Dopaminergic cocktail "of 1)Hydergine 2mg tid for 3 days, then add 2)Symmetrel 100 - 200 mg tid for 3 days, then add 3) deprenyl 5mg bid for 3 days, then, if necessary add 4) bupropion 100 mg tid (it takes 4 - 6 wks to work) Drug Tolerance-large doses of inositol (inositol poorly penetrates the blood-brain barrier) affects the sensitization of the alpha-1 receptor and can sometimes reverse tolerance to a previously helpful medication.
Case Report16 yr old, home bound for 2 years with CFS, too cognitively impaired toreceive home tutoring. She initially had excellent response to Zantac, naphazoline, nimodepine, oxytocin, and several antidepressants, but thebenefit was always short-lived. After taking one gram of inositol she felt considerably better and was encouraged to resume agents to which shehad developed tolerance. As long as she continued to take inositol 1 gmqid, these medications were again effective. She has returned to high school and will be graduating shortly.
BeatCfsAndFms.org
If the alpha-1 receptors are clogged (e.g. by a pesky heavy metal molecule), one would feel fatigued. The following things can clog NA alpha-1 receptors: antagonist drugs, lead, mercury, cadmium, sulfur-toxins, over 70,000 manmade chemicals, and several natural toxins
the person at hedweb.org mentions DHEA to wash drugs.
alsoPAGE URL:http://www.beatcfsandfms.org/html/BrainChem.html
Noradrenaline (NA) alpha-1 and alpha-2 receptors
With the noradrenaline (NA) neurotransmitter, for example, two of the receptors are called "alpha-1" and "alpha-2" (catcher with #1 on his shirt, and catcher with #2 on his shirt, each with their own special phone line). The Alfa-1-receptors stimulate the conversion of liver molecules to sugar molecules (glucogenolysis), resulting in more glucose in the blood. Alpha-1 also stimulates the consumption of oxygen (O2) by the cells and stimulates the conversion of fatty acid in blood to energy. All of these alpha-1 items result in more energy for the person. If the alpha-1 receptors are clogged (e.g. by a pesky heavy metal molecule), one would feel fatigued. The following things can clog NA alpha-1 receptors: antagonist drugs, lead, mercury, cadmium, sulfur-toxins, over 70,000 manmade chemicals, and several natural toxins. To see examples of studies on noradrenaline receptors, please click here.Noradrenaline Agonists
Provigil (Modafinil = Modiodal) is an example of an NA-Agonists that is FDA approved. It stimulates the noradrenaline alpha-1 receptor, and subsequently increases glucose (sugar) in blood (due to increase glucogenolysis) and increases oxygen to cells, which results in more biochemical energy (i.e. less fatigue). Several NA-Agonists have been used extensively in Europe, including Ordinal Forte, and Adrafinil (Omifon) and Modafinil. To learn more about Provigil, click here. The NA-Agonists tend to not be habit forming, unlike some of the serotonin Agonists.hope the last sentence is true:-)
> Thanks for info, John.
> One more question, you wrote that Adrafinil eventually became less
> effective for you. I suspect that's quite normal since Adrafinil seems
> to me more a stimulant rather than a conventional antidepressant. How
> quickly did you develop resistance ? Did you increase your dosage then ?
>
> Thanks a lot,
> J.L.
>
> > Hello John,
> >
> > For liver protection and health, consider supplements of the herb Milk Thistle and also SAMe. Take the daily dose of Milk Thistle extract stated on the bottle, and one 200mg tab of SAMe per day, or one every other day. Both of these are very protective and rejuvenating for the liver.
> >
> > Adrafinil helps me in an amazing way, similar to what you described. I'm glad to hear someone else is doing real well with it. For me, dozens of other medicines tried over many years didn't come anywhere close to working as well. I order a new supply when my current supply is only enough to last one month. Like you, I definitely would not want to go without!
> >
> > You might want to get a liver test once every six months just to be on the safe side. Continuous use of Milk Thistle and SAMe should help keep everything normal. If your tests indicate elevated enzymes, you might have to lower your dose for a while so they can return to normal. Again though, I think the supplements I mentioned will be good insurance in preventing any problems.
> >
> > I wish Adrafinil had some serious funding behind it. I could easily envision it taking over Prozac's popularity.
> > John
poster:Maniz
thread:50273
URL: http://www.dr-bob.org/babble/20001130/msgs/50349.html