Posted by Bob on December 13, 2000, at 9:25:26
In reply to Re: thyroid augmentation, posted by SLS on December 13, 2000, at 6:29:33
> > I have been augmenting my AD (Celexa - 20mg daily) with both T3 - 12.5mcg, and T4 - 12.5mcg daily for quite some time. Originally I started augmentation about 3 to 4 months ago with just T3 and got a fantastic response for about a week with just 25mcg. Then it started to wane, and I upped it to 50. I was good again, until that started to wane, and I started to also exhibit hyperthyroid symptoms - sweating, tachycardia, etc. I reduced my dose back down to 12.5mcg, and then began adding T4 at 12.5mcg. I felt better again for about 3 to 4 days. After yet another waning, I increased both T3 and T4 to 25mcg levels. I felt better again, then it waned again. The pattern was incessant, so I finally brought both meds down to 12.5mcg. I have been at this level for a about 2 months now, and in general don't feel that well anymore. Ever since that first experiment with thyroid augmentation, I've been searchng for those original feelings. I hadn't felt that good in years - confident, strong, relaxed, and refreshed. It seems to have all gone away now, and the original response I had is completely elusive. I'm contemplating getting off the augmentation strategy altogether.
> >
> > Has anyone else experienced this course of events, where the thyroid augmentation helps for awhile, but then bogs down into symptoms of hyperthyroidism? It was so good at first!
>
>
> One of the things thyroid hormone does is to make norepinephrine receptors more sensitive. My knee-jerk reaction to your situation would be to ask you if you have ever tried desipramine (Norpramin) or any other tricyclic antidepressant. You may want to think about simply adding desipramine to what you are already taking, including thyroid hormone.
>
>
> - Scott
Way back in the beginning of my treatment, I tried Anafranil and was on it for the good part of a year. It was very unpleasant for me. I have since done everything in my power to avoid taking anything else with even a hint of tricyclic action. I realize that I respond well to norepinephrine action, as I responded well to Effexor (although that eventually bogged down). I wish that Roboxetine/Edronax would become available. I've heard that poops out for people also, though.Thank you for your input, by the way.
poster:Bob
thread:50460
URL: http://www.dr-bob.org/babble/20001130/msgs/50487.html