Posted by Sulpicia on February 11, 2001, at 18:15:44
In reply to Adderall tolerance , dosing, etc., posted by JohnX on February 11, 2001, at 7:01:29
>
> I'm curious what sort of sensitization (poop-out)
> issues other people on this group have had
> with Adderall.
>
> I've taken it twice as a last ditch effort to
> treat depression.
>
> The 1st time I took it standalone and it it would
> poop out after about every 3 days.
> I took it once a day in the morning with a
> mean dose of ~20 mg. I would always seem to get
> erratic responses. One day 10mg drove me frantic.
> Another day 30 mg did nothing.
>
In my experience this is an extremely unusual situation.
Can you be more specific about what you mean by "poop out?"
Do you mean that you became depressed again or where no longer experiencing the euphoria
that can accompany the initial doses of adderall?
Is depression an ironclad diagnosis? Can you correlate
what you ate with the days on which the adderall didn't work?
There are some food interactions.
I take adderall 40 mgs [20am,10,10] for ADD; also dx depression
for 4th time so I took paxil 30 mgs -- the paxil potentiated the effect
of the adderall. I hated what paxil did to my muscles [I run, or I used to!]
so I'm switching to old friend tofranil, which dampens the adderall.
In general, people with ADD tend not to develop a tolerance -- god knows why.
3 days must be some kind of record but I have to admit I have come
across several people who didn't respond to adderall at all.
> Curiously, I tried Adderall again with Klonopin
> to reduce fatigue.
Are you only on a benzo for depression?????This time I always got the
> same Adderall response at 20mg. I found this strange
> and actually found an abstract describing how
> clonazepam (Klonopin) could prevent amphetamine
> sensitization. Unfortunately I got poop-out on Klonopin,
> another addictive med, and everything went to *ell.
Sorry -- sounds like you were very nearly pulled in twain here.
> I have looked at the addiction pathway of amphetamine,
> and their is a simple and interesting medication in
> the pipeline which may prevent tolerance issues,
> without addiction to the additive medication.
> (Another guru in this NG is studying it).
That should be interesting, especially since the problem
with amphetamine is that simultaneously blocks dopamine reuptake
and increases the levels by shoving more of it out of the
little storage pockets in the neuron -- god I hope I'm remembering
correctly! Please forgive my flubs. It would be a neat trick
to alter secretion and blockage w/out problems.
> Anyones comments on Adderall dosing issues welcomed.
> I'm very curious if my sensitization is much
> greater than the average joe's.You react very strangely to this med -- and believe me,
I've heard a few! The only thing that can be deduced
here is that the meds were expired, you ate something
that inactivated it, or your system doesn't tolerate it
very well.
Have you tried dexedrine or could you try adderall as
an add-on with an appropriate SSRI?
I wonder about 10 mgs making you frantic; I imagine you've
tried mood stabilizers for depression like lamictal? Or lamictal
in combo with an SSRI?Sorry not to be of more help. I do hope you find something that
works for you.
>Liz
>
>
poster:Sulpicia
thread:53733
URL: http://www.dr-bob.org/babble/20010131/msgs/53767.html