Posted by SLS on February 12, 2001, at 18:47:10
In reply to Re: Re; psychopharmacology of lamictal, posted by JohnX on February 12, 2001, at 4:42:44
> Any idea why Lamictal would show more of an
> antidepressant effect than say Depakote, which
> also blocks sodium channels and reduces the
> excitation of glutamate? Of course Depakote
> also does a job interfering with calcium
> channels and enhancing gaba.
>
> -John
My guess is that lamotrigine may possess a pro-dopaminergic property that is independent of its reduction of extracellular glutamate concentrations. It seems to help prevent MPTP-induced dopamine depletions in laboratory animals. It also has a restorative effect upon MPTP-treated mice when combined with l-dopa. It shares this property with selegiline (l-deprenyl). In addition, there are anecdotal reports that lamotrigine has produced tics (abnormal movements) and Tourette's Syndrome in a manner similar to methylphenidate or amphetamine.
- Scott
poster:SLS
thread:53739
URL: http://www.dr-bob.org/babble/20010212/msgs/53829.html