Posted by SLS on February 16, 2001, at 20:13:47
In reply to Beta3-Adrenergic Receptors, posted by Cam W. on February 16, 2001, at 11:02:59
Hi Cam.
> > By the way, I read somewhere that the diabetes and insulin insensitivity sometime brought about by olanzapine or clozapine is due to these drugs' actions at 5-HT1b receptors on the beta cells (Islets of Langherhans) of the pancreas.> Scott - Are you thinking about beta3-adrenergic receptors? They are expressed primarily in fat (adipose) tissue, where they regulate energy metabolism and thermogenesis (turning fat into heat and energy). It is signalled by norepinephrine.
ago and I haven't heard what has happened to this research.> Silbutramine increases norepinephrine peripherally at the beta3-adrenergic receptors in fat tissue. This stimulates thermogenesis and oxygen consumption, supposedly leading to weight loss. I haven't heard any extraordinary claims about this drug, though (yet). Perhaps adding them to 5-HT2C receptor agonists will increase it's potency (when they find aa selective effective and safe 5-HT2C receptor agonist).
I can't remember where I read this, if I indeed read it at all. The reference definitely involved the pancreatic beta cells. When I looked back on Medline, I couldn't find anything on it. I guess I read it in a PB dream. Oh well, never mind. :-)
- Scott
poster:SLS
thread:54100
URL: http://www.dr-bob.org/babble/20010212/msgs/54190.html