Posted by Sunnely on February 23, 2001, at 21:47:07
In reply to Re:SSRIs/TARDIVE DYSKINESIA?, posted by pat123 on February 23, 2001, at 13:19:28
SSRIs (selective serotonin reuptake inhibitors), via their serotonergic effect can affect dopamine. Actually, serotonin is a "neuromodulator" of dopamine i.e., a neurotransmitter that affects the action of another neurotransmitter. Specifically, serotonin inhibits the action of dopamine. This is postulated mechanism as to how SSRIs cause movement disorders, in particular extrapyramidal symptoms or EPS (e.g., dystonia, akathisia, parkinsonism). There have been anecdotal reports of SSRIs causing dyskinetic disorder (e.g., tardive dyskinesia or TD).
As of December 31, 1996, postmarketing surveillances indicated 383 cases of dystonia, 403 cases of akathisia, 503 cases of parkinsonism, and 120 cases of tardive dyskinesia associated with the use of fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil). Given that patient marketing of the aforementioned SSRIs is estimated to exceed 30 million, movement disorders associated with SSRIs use are uncommon.
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> > I think there's been some vague talk in the medical press recently regarding reports possibly linking long-term SSRI use with movement disorders...
> >
> > Jah.
>
> SSRI DO NOT effect dopamine so there is no possibility of movement disorders !
>
> Pat
poster:Sunnely
thread:54523
URL: http://www.dr-bob.org/babble/20010221/msgs/54723.html