Posted by Cam W. on February 27, 2001, at 6:47:27
In reply to Re: Anyone using Trazedon to help sleep w/SRRI's ?, posted by Sunnely on February 26, 2001, at 21:43:37
Sunnely - I have heard of this "electric shock" in the head. It seems to be a long-term symptom of seroternic drug withdrawl and can last months. It has been described as a "kind of vibration/crackling or short-lived pop/buzz" in the head. This is one side effect that has made me wonder on several occasions. It does seem to start upon abrupt withdrawl of the short acting serotonergic agents and can even continue when a weaning regimen is reinstated. I have never personally heard of someone mention this, but have read of it in the literature. I do not know what kind of weaning process was eventually initiated,
either. It seems to be a real phenomenon, though, and could have to do with either a problem of reinstating appropriate levels of the serotonin reuptake transporter, the 5-HTB1 receptor, or the norepinephrine reuptake transporter; all of which have recently been shown to be linked to one another. I have a feeling (and it is just a feeling) that the inability of certain people's biochemistry to "renormalize' or upregulate the norepinephrine transporter upon withdrawl of the serotonergic agent may be at the heart of these "electric shocks".Do you have any comments or thoughts on this? - Cam
poster:Cam W.
thread:54758
URL: http://www.dr-bob.org/babble/20010221/msgs/54970.html