Re: Is half-life the whole story?

Posted by JohnX on March 10, 2001, at 1:41:06

In reply to Is half-life the whole story?, posted by JohnM on March 9, 2001, at 18:58:01

> I seem to find contradictions with half-life of a med and its duration of effect in the CNS. For example compare Ativan to Valium. Ativan, although it has a much shorter half life, supposedly has a longer duration of effect than Valium.
>
> From a nursing pharmacology book I looked at, it seems that Tranxene (clorazepate) or Serax (oxazepam) would be my best bet.
I believe the 1/2 life is with respect to how long it takes for the body to clear 1/2 of the medication from the blood plasma. The longer the med is in the blood plasma, the more time it has to penetrate the blood/brain barrier. How long it takes for the the medication to be deaminated within the brain may be different. Anybody correct me if I'm wrong.
-John

Thread

Please suggest a long-acting benzodiazepine JohnM 3/4/01
Re: Please suggest a long-acting benzodiazepine Jeff 3/5/01
Re: Please suggest a long-acting benzodiazepine Daveman 3/6/01
Re: Please suggest a long-acting benzodiazepine JohnX 3/7/01
Thanks John X JohnM 3/7/01
Re: Thanks John X » JohnM JohnX 3/9/01
Re: Please suggest a long-acting benzodiazepine jb 3/9/01
Is half-life the whole story? JohnM 3/9/01
Re: Is half-life the whole story? JohnX 3/10/01

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