Posted by sweetmarie on April 7, 2001, at 11:38:48
In reply to Re: ANYONE HAD SUCCESS WITH PARNATE?, posted by BK on April 6, 2001, at 17:51:59
> > I tried Nardil, another MAOI, and had tremendous sucess initially. Unfortunately, it lasted only three months and then I actually started to feel worst on it. I tried Nardil again several years later, but it never seemed to kick in as it once had. From reading herein, i noticed that this is not an uncommon effect with Nardil.
>
> I've tried just about every other AD since and nothing has seemed to help my "treatment-resistant" depression. I'm currently taking Adrafinil, but haven't had much sucess with that either.
>
> I strongly suggest that you give a MAOI a try. The dietary restrictions are significant, but not totally life changing. If this drug works for you, it will be well worth the dietary sacrifices. Good luck and let me know (and everyone else) how it works for you. Anyone out there who has found an effective replacement for Nardil, please let me know.
>
> BKHi
I had a similar MAOI (Nardil) experience, but for me it only worked for 3 weeks.
It seems to me that with cases of `treatment resistant` depression (which I also suffer from, in a very severe form), combination therapy is probably the only answer (taking more than one medication at a time).
I`ve been trying loads of different meds over the past 10 years, and still absolutely no luck (depression not alleviated at all). However, there does come a point when your consultant will (or should) consider a combination of meds as opposed to just one. Resistance to medication, does not need to mean resistance to all medication, it just means that a suitable one (or more than one) has not been found as yet.
I am due to be treated for my resistant depression at a unit which specifically deals in this type of condition (resistant or `refractory` depression). The bloke who will be treating me is a specialist in this area, and it`s his opinion that `treatment resistant depression` is a misnomer. In other words, it implies that the patient/sufferer has been resistant to treatment, where in fact the right treatment has not yet been found. Basically, the patient/sufferer has been failed by the treatment. I don`t know whether this makes sense, the way I`ve put it. Basically what he`s saying is that the patient has been failed by the medication, and by implication by those administering it. I hope that this makes some sense.
It`s easy to feel that you`ve exhausted all avenues - I do, most of the time. It`s also scary to contemplate the possibility that NO medication will ever be found. This is unlikely to be the case - as we speak (write), new treatments are coming onto the market, being researched etc.
I write this to convince myself as much as anything. I`ve been very ill for a very long time, and find it hard to keep going and remain optimistic. However, I do recognise this to be `depression-speak`, which is very hard to get beyond.
This thing cannot last forever.
Anna.
poster:sweetmarie
thread:58903
URL: http://www.dr-bob.org/babble/20010403/msgs/59022.html